塞来昔布对腱鞘巨细胞瘤术后患者的疗效分析

Effects of Celecoxib on Postoperative Patients with Giant Cell Tumor of Tendinous Sheath

目的探讨塞来昔布对腱鞘巨细胞瘤术后患者的治疗效果及预后。方法选择我院2013年4月-2017年3月期间接受手术治疗的32例腱鞘巨细胞瘤患者,随机分为对照组和实验组,每组16例。对照组给予术后常规治疗及护理方案,实验组在对照组的基础上口服塞来昔布胶囊,0.2 g/次,2次/d,连续服用3个月,评价两组患者的关节屈伸活动度、KPS评分及复发率。结果两组患者术后关节屈伸活动度、KPS评分均无显著差异(P>0.05);术后6个月,实验组的关节屈伸活动度、KPS评分及复发率均明显优于对照组(P<0.05)。结论塞来昔布用于腱鞘巨细胞瘤术后治疗,可改善患者生存状况,降低复发率,值得临床推广。

Objective To investigate the efficacy and prognosis of celecoxib in the treatment of giant cell tumor of tendon sheath.Methods A total of 32 cases of giant cell tumor of tendon sheath after operation in our hospital between April 2013 and March 2017 were divided into control group and experiment group,with 16 cases in each group.The control group was treated by conventional postoperative treatment and nursing.The experiment group was treated with celecoxib 200 mg daily for three months on the basis of treatment of the control group.Follow-up was performed to evaluate the joint flexion and extension activities,KPS score and recurrence rate.Results After operation,the joint flexion and extension activities and KPS scores had no statistical differences(P>0.05).After six months,the joint flexion and extension activities and KPS scores of the experiment group were significantly better than that of the control group(P<0.05).The recurrence rates was also lower in experiment group than in control group(P<0.05).Conclusion Celecoxib in post-operative treatment of pigmented villonodular synovitis can improve the quality of life and reduce the recurrence rate of patients.It is worthy of clinical promotion.