替罗非班联合奥扎格雷治疗进展性脑梗死的疗效及对血小板功能的影响

Efficacy of Tirofiban Combined with Ozagrel in Treatment of Progressive Ischemic Stroke and its Influence on Platelet Function

目的:观察替罗非班联合奥扎格雷治疗进展性脑梗死(PIS)的疗效及对血小板功能的影响。方法:将2017年1～12月我院治疗的114例PIS患者作为研究对象,应用随机数表法分为两组,各57例。观察组接受替罗非班、奥扎格雷治疗,对照组接受奥扎格雷治疗。观察两组临床疗效、治疗前后神经功能及血小板功能变化情况等。结果:较对照组相比,观察组总有效率(92. 98%)相对较高,差异有统计学意义(P <0. 05);治疗前按照美国国立卫生研究院卒中量表(NIHSS)评分、P选择素(P-selectin)、血小板聚集率对比,差异无统计学意义(P> 0. 05);治疗后较对照组相比,观察组NIHSS评分(6. 22±1. 17)分、P-selectin(10. 19±2. 31)μg·L^(-1)、血小板聚集率(27. 98±3. 26)%相对较低,差异有统计学意义(P <0. 05)。结论:替罗非班联合奥扎格雷是PIS治疗中较为安全且有效的用药方案,利于促进患者神经功能恢复,改善血小板功能。

Objective:To observe the efficacy of tirofiban combined with ozagrel in treatment of progressive ischemic stroke(PIS)and its influence on platelet function.Methods:114 PIS patients who treated in the hospital from January to December 2017 were selected as the research object,and they were divided into two groups according to the random number table,with 57 cases in each group.The observation group was given tirofiban combined with ozagrel,while the control group was treated with ozagrel.The clinical efficacy,nerve function,changes of platelet function in two groups were observed.Results:The total effective rate of observation group(92.98%)was higher than that of control group,and there was statistical significant of difference(P<0.05).Before treatment,there was no statistical significant of difference in the National Institute of Health Stroke Scale(NIHSS),P-selectin,platelet aggregation rate between the two groups(P>0.05).After treatment,the NIHSS score,P-selectin,platelet aggregation rate in observation group[(6.22±1.17)points,(10.19±2.31)μg·L^-1,(27.98±3.26)%]were lower than those in control group,and there was statistical significant of difference(P<0.05).Conclusion:Tirofiban combined with ozagrel in treatment of PIS is safe and effective,it can promote recovery of nerve function and improve platelet function.