胃食管反流病对哮喘患者肺功能影响的研究

Effect of gastroesophageal reflux disease on lung function in patients with asthma

目的探讨胃食管反流病对哮喘患者肺功能的影响。方法收集2015年5月至2017年8月新疆维吾尔自治区人民医院收治并确诊哮喘226例患者的临床资料,根据是否合并有胃食管反流病(GERD)患者分为GERD组102例和非GERD组124例,比较2组患者FEV1占预计值%、FVC占预计值%及FEV1/FVC%等肺功能指标。结果 GERD发生率45. 1%(102/226),GERD组患者FEV1占预计值%、FVC占预计值%及FEV1/FVC%,明显低于非GERD组,差异有统计学意义(P <0. 05)。结论哮喘与GERD密切相关,GERD对哮喘患者肺功能影响大,GERD与哮喘是因果还是伴随关系仍需进一步研究。

Objective To investigate the effect of gastroesophageal reflux disease on lung function in patients with asthma. Methods There were admitted to Department of respiration and diagnosed asthma patients 226 cases who from May 2015 to August 2017 in the people’s hospital of Xinjiang Uygur Autonomous Region,according to whether complicated with GERD were divided into GERD group and non GERD group,compared two groups of patients with FEV1%,FVC% and FEV1/FVC% pulmonary function index.Results The incidence of GERD was 45. 1%(102/226),GERD group of FEV1 %,FVC% and FEV1/FVC% were significantly lower than non GERD group,and the difference was statistically significant( P <0. 05). Conclusion GERD is closely related with asthma,GERD has great influence on the pulmonary function of asthma patients,GERD and asthma is causal or accompanying relationship still need further study.