不同年龄段乳腺癌的临床特点比较

Clinical characteristics of breast cancer in different age groups

目的:分析不同年龄段发病的乳腺癌患者临床、病理特点及治疗方案选择的差异。方法:收集2009年至2016年就诊于本院的1207例乳腺患者临床资料、病理特点、治疗方案,分为三组:青年组(年龄≤35岁)、中年组(35<年龄≤50)、老年组(年龄>50岁)进行回顾性分析。结果:共入组1207例病人,青年组44例、中年组595例,老年组568例。初潮年龄、怀孕次数、生产次数、BMI在三组中差异有统计学意义。两两比较结果发现,青年组与中年组相比BMI差异有统计学意义(P <0.001),青年组与老年组相比,生产次数及BMI差异有统计学意义(均P <0.001),中年组与老年组相比初潮年龄、生产次数、怀孕次数及BMI差异有统计学意义(P=0.028、P <0.001、P=0.001、P=0.019)。年龄分组与月经状态呈显著相关性(r=0.765,P <0.001)。年龄分组与彩超BI-RADS分类呈显著相关性(r=0.125,P <0.001)。青年组行穿刺活检的高于中年组(36.4%VS 20.2%,P=0.011),高于老年组(36.4%VS20.1%,P=0.001)。青年组保乳手术率高于中年组(22.7%VS 9.3%,P=0.05)、高于老年组(22.7%VS 5.7%,P <0.001)。PR表达中年组高于老年组(70.3%VS 60.4%,P <0.001)。中年组化疗者高于老年组(81.5%VS 69.9%,P <0.001)。放疗选择老年组低于青年组(26.2%VS 52.3%,P <0.001),低于中年组(26.2%VS 38.2%,P <0.001)。中年组选择内分泌治疗者多于老年组(73.3%VS 65.5%,P=0.004)。结论:中年组初潮年龄比老年组更早;生育次数、BMI随年龄增长而逐渐上升。高龄组的肿块彩超检查BI-RADS分类也更高;不同年龄组治疗策略的选择不同。

Objective:To analyze the clinicopathological characteristics and treatment options of breast cancer patients in different age groups.Methods:The clinical data,pathological characteristics and treatment plan of 1207 breast patients in our hospital from 2009 to 2016 were retrospectively analyzed.They were divided into three groups:young group(age≤35 years),middle age group(35<age≤50),and elderly group(age>50 years).Results:There were 1207 cases in the group,44 cases in the young group,595 cases in the middle age group and 568 cases in the elderly group.The age of menarche,number of pregnancies,parity and BMI were significantly different among the three groups.The results of pairwise comparison showed that there was a significant difference in BMI between the young group and the middle age group(P<0.001),and there was a significant difference in parity and the BMI between the young group and the old group(all P<0.001).There was a significant correlation between age group and menstrual state(r=0.765g,P<0.01)There was a significant correlation between age group and color Doppler BI-RADS classification(r=0.125)(P<001)The rate of puncture biopsy in the young group was higher than that in the middle age group(36.4%VS 20.2 P=0.011)and higher than that in the elderly group(36.4%VS 20.1g P=001).The rate of breast conserving surgery in the young group was higher than that in the middle-aged group(22.7%VS 9.3%,P=0.05)and elderly group(5.7%)(P<0.005).The expression of PR in middle age group was higher than that in elderly group(70.3%VS 60.4%P<0.001).The number of chemotherapy patients in middle age group was higher than that in old group(81.5%VS 69.9%P<0.001).The selection of radiotherapy in the elderly group was lower than that in the young group(26.2%VS 52.3%,P<0.01)Lower than middle age group(26.2%VS 38.2%,P<0.001).The number of patients in middle age group who chose endocrine therapy was more than that in old group(73.3%VS 65.5%,P=0.004).Conclusion:The age of menarche in middle-aged group was earlier than that in old group.The parity,BMI gradually increased with age.The BI-ARADS classification of masses in the elderly group was higher.Treatment strategies were different in different age groups.