降脂护肝方联合瑞舒伐他汀钙片治疗痰瘀互结型非酒精性脂肪肝的临床观察

Clinical observation of Jiangzhi Hugan Recipe combined with rosuvastatin calcium tablets in the treatment of non-alcoholic fatty liver disease

目的:探讨中西医结合治疗对痰瘀互结型非酒精性脂肪肝患者相关指标及中医证候积分的影响。方法:选取我科收治的128例痰瘀互结型非酒精性脂肪肝患者作为研究对象,随机分为治疗组(64例)和对照组(64例)。对照组应用瑞舒伐他汀钙片治疗,治疗组在对照组治疗的基础上加用降脂护肝方,10d为1个疗程,治疗共3个疗程。比较两组肝功、血脂、胰岛素抵抗指数(HOMA-IR)、鸢尾素(Irisin)、超氧化物歧化酶(SOD)、丙二醛(MDA)、体重指数(BMI)、腰围(WC)、肝/脾CT比值及中医症候积分。结果:治疗组中医症候疗效疗效(82.82%)明显高于对照组(65.62%),其差异具有统计学意义(P<0.05);两组患者治疗前各指标均无差异(P>0.05);较治疗前比较,两组治疗后各指标水平均有显著改善(P<0.05),且治疗组较对照组各指标改善更加明显,具有统计学差异(P<0.05)。结论:中西医结合治疗能够改善患者的症状,能够取得良好的临床疗效,且具有一定抗氧化应激的作用,值得临床推广或进一步研究。

Objective:To investigate the influence of integrated traditional Chinese and Western medicine on the related indexes and TCM syndrome scores of patients with non-alcoholic fatty liver disease.Methods:A total of 128 patients with non-alcoholic fatty liver disease who were admitted to our department from January 2017 to May 18,2017 were enrolled in the study.According to the hospital admission record number,they were randomly divided into treatment groups and control group,with 64 cases in each group.The control group was treated with rosuvastatin calcium tablets.The treatment group was treated with Jiangzhi Fanggan Recipe on the basis of the control group.The treatment was performed for 10 days for a total of 3 courses.Liver function,blood lipids,insulin resistance index(HOMA-IR),iris(Irisin),superoxide dismutase(SOD),malondialdehyde(MDA),body mass index(BMI),waist circumference(WC),Liver/spleen CT ratio and TCM syndrome scores were compared between the two groups.Results:The curative effect of TCM symptom in the treatment group(82.82%)was significantly higher than that in the control group(65.62%),and the difference was statistically significant(P<0.05).There was no difference between the two groups before treatment(P>0.05).Compared with before treatment,the levels of each index were significantly improved after treatment(P<0.05),and the improvement of the treatment group was more significant than that of the control group(P<0.05).Conclusion:The combination of traditional Chinese and Western medicine can improve the symptoms of patients,achieve good clinical efficacy,and have certain anti-oxidative stress effects,which is worthy of clinical promotion or further research.