Pgp1和FoxP3在结直肠癌中的表达及其与预后的关系

Expression of Pgp1 and FoxP3 in colorectal cancer and their relationship with prognosis

目的探讨P-糖蛋白1(Pgp1)和核转录因子蛋白3(FoxP3)在结直肠癌中的表达及其与预后的关系。方法选取2012年2月至2015年2月我院保存的结直肠癌标本106例,同时选取癌旁组织标本64例作为对照,采用免疫组化染色法检测Pgp1和FoxP3表达,同时根据Pgp1和FoxP3表达情况将患者分为Pgp1和FoxP3双阴性表达(A组),Pgp1单阳性表达(B组)、FoxP3单阳性表达(C组),Pgp1和FoxP3双阳性表达(D组)。结果结直肠癌组织Pgp1和FoxP3蛋白阳性表达率分别为63.21%和43.40%,明显高于癌旁组织(P<0.05);结肠癌Pgp1蛋白阳性表达率为78.95%,明显高于直肠癌(P<0.05);FoxP3表达与患者临床病理特征以及治疗方案无明显关系(P>0.05);B组中位总体生存时间为52个月(95%CI:40.01～63.99),明显高于A组、D组和C组(P<0.05);A组和D组中位总体生存时间为40个月(95%CI:31.20～48.80)和34个月(95%CI:30.74～37.26),明显高于C组的24个月(95%CI:18.56～29.44),比较差异具有统计学意义(P<0.05)。结论 Pgp1和FoxP3表达与结直肠癌临床病理特征关系较弱,其中仅Pgp1表达与肿瘤位置有一定相关性;Pgp1和FoxP3表达与结直肠癌患者预后有一定关系,其中Pgp1阳性表达,FoxP3阴性表达者预后较好。

Objective To investigate the expression of P-glycoprotein 1(Pgp1)and forkhead or winged helix transcription factor proteins 3(FoxP3)in colorectal cancer and its relationship with prognosis.Methods A total of 106 specimens of colorectal cancer in our hospital from February 2012 to February 2015 were selected,and 64 specimens of paracancerous tissue specimens were selected as control,the expression of Pgp1 and FoxP3 were detected by using immunohistochemical staining;according to the expression of Pgp1 and FoxP3,the patients were divided into 4 groups,double negative expressions of Pgp1 and FoxP3(group A),single positive expression of Pgp1(group B),single positive expression of FoxP3(group C),double positive expression of Pgp1 and FoxP3(group D).Results The positive expression rates of Pgp1 and FoxP3 protein in colorectal cancer tissues were 63.21%and 43.40%,which were significantly higher than those in adjacent tissues(P<0.05);The positive expression rate of Pgp1 protein in colon cancer was 78.95%,which was significantly higher than that in rectal cancer(P<0.05);There were no significant relationship between FoxP3 expression and clinicopathological characteristics and treatment regimens(P >0.05);The median survival time in group B was 52 months(95%CI:40.01~63.99),which was significantly higher than that in group A,group D and group C(P<0.05);The median survival time of group A and group D were 40 months(95%CI:31.20~48.80)and 34 months(95%CI:30.74~37.26),which were significantly higher than that of group C(95%CI:18.56~29.44),and the difference was statistically significant(P<0.05).Conclusion The expression of Pgp1 and FoxP3 are weakly correlated with the clinicopathological characteristics of colorectal cancer,only Pgp1 expression is related to tumor location;The expression of Pgp1 and FoxP3 are related to the prognosis of colorectal cancer,patients with Pgp1 positive expression and FoxP3 negative expression have better prognosis.