补元聪脑汤联合针灸对老年痴呆(肾虚痰瘀型)患者疗效及MMSE、Hcy、Aβ的影响

Curative Effects of Buyuan Congnao Decoction Combined with Acupuncture on Senile Patients with Dementia (Kidney Deficiency and Phlegm Stasis Pattern) and Effects on MMSE,Hcy and Aβ

目的:观察补元聪脑汤联合针灸对老年痴呆(肾虚痰瘀型)患者疗效及简易精神状态评价量表(MMSE)、同型半胱氨酸(Hcy)、β淀粉样蛋白(Aβ)的影响。方法:选取2014年7月至2016年8月延安大学附属医院收治的肾虚痰瘀型老年痴呆患者98例作为研究对象,按照随机数字表法分为观察组和对照组,每组49例,对照组给予针灸治疗,观察组在对照组基础上联合补元聪脑汤治疗。观察2组临床疗效、中医症状积分、MMSE、Hcy以及Aβ水平。结果:观察组总有效率87. 76%显著高于对照组69. 39%(P <0. 05);治疗后2组倦怠乏力、智能减退、肢体困重、言语颠倒、小便失禁、头晕耳鸣评分显著低于治疗前(P <0. 05),且观察组显著低于对照组(P <0. 05);治疗后2组定向力、语言能力、注意力和计算力、记忆力评分显著高于治疗前(P <0. 05),且观察组显著高于对照组(P <0. 05);治疗后2组Hcy和Aβ水平显著低于治疗前(P <0. 05),且观察组显著低于对照组(P <0. 05)。结论:补元聪脑汤联合针灸能够有效提高改善肾虚痰瘀型老年痴呆患者Hcy和Aβ水平,提高认知功能和临床疗效。

Objective:To observe the curative effect of Buyuan Congnao decoction combined with acupuncture on senile patients with dementia (kidney deficiency and phlegm stasis pattern) and effect on MMSE,homocysteine (Hcy),amyloid beta-protein (Aβ).Methods:Ninety-eight patients with dementia (kidney deficiency and phlegm stasis pattern) who were admitted and treated in Yanan university affiliated hospital from July 2014 to August 2016 were selected as the study objects,and were divided into observation group and control group,with 49 patients in each group according to random number table.The control group was treated with acupuncture,and the observation group was treated combined with Buyuan Congnao decoction on the basis of conventional treatment.Clinical effect,TCM symptom score,MMSE,Hcy and Aβ levels were observed in the two groups.Results:The total effective rate of the patients in the observation group was 87.76%,which was significantly higher than that of 69.39% of the control group (P<0.05).After treatment,scores of fatigue and lack of strength,mental decline,limb heaviness,verbal reversal,incontinence,dizziness and tinnitus were significantly lower than those before treatment (P<0.05),and those of the observation group were significantly lower than those of the control group (P<0.05).After treatment,scores of orientation,language ability,attention and calculation ability,memory were significantly higher than those before treatment (P<0.05),and those of the observation group were significantly higher than those of the control group (P<0.05).After treatment,Hcy and Aβ levels were significantly lower than those before treatment (P<0.05),and those of the observation group were significantly lower than those of the control group (P<0.05).Conclusion:Buyuan Congnao decoction combined with acupuncture can effectively improve Hcy and Aβ levels of senile patients with dementia (kidney deficiency and phlegm stasis pattern),and can improve cognitive function and clinical effect.