肾炎康复片与雷公藤多苷片联合对系膜增生性肾小球肾炎患者肾功能和血清生化指标的影响

Effects of Shenyan Kangfu Tablets Combined with Tripterygium Polyglycoside Tablets on the Renal Function and Serum Biochemical Indicators of Patients with Mesangial Proliferative Glomerulonephritis

目的:探讨肾炎康复片与雷公藤多苷片联合对系膜增生性肾小球肾炎(MsPGN)患者肾功能和血清生化指标的影响。方法:选取2015年1月至2016年12月北京王府中西医结合医院收治的MsPGN患者62例,按照随机数字表法分为对照组和观察组,每组31例。对照组采用常规西药治疗,观察组在对照组的基础上加用肾炎康复片联合雷公藤多苷片治疗,2组均连续治疗1个月。比较2组临床疗效及治疗前后中医证候积分、肾功能指标及生化指标变化。结果:治疗后观察组的总有效率为93. 55%,显著高于对照组的74. 19%(P <0. 05);与治疗前比较,2组疲倦乏力、口干、盗汗、浮肿、蛋白尿及血尿等中医证候积分,血清肌酐(Scr)、血尿素氮(BUN)、肿瘤坏死因子(TNF-α)、总胆固醇(TC)、三酰甘油(TG)和尿蛋白(UAER)均显著下降,差异有统计学意义(P <0. 05),且观察组明显低于对照组,差异有统计学意义(P <0. 05),治疗后2组肾小球滤过率(GFR)和血清白蛋白(ALB)水平较治疗前升高,且观察组改善优于对照组,差异有统计学意义(P <0. 05)。结论:肾炎康复片与雷公藤多苷片联合治疗MsPGN可有效改善患者中医证候及肾功能,改善血清生化指标,疗效明显。

Objective:To explore the effects of Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets on the renal function and serum biochemical indicators of patients with mesangial proliferative glomerulonephritis.Methods:A total of 62 cases of patients with mesangial proliferative glomerulonephritis (MsPGN) in Beijing Wangfu Integrated Chinese and Western Medicine Hospital from January 2015 to Deceomber 2016 were selected and divided randomly into observation group and control group,with 31 cases in each group.The control group were treated with routine western medicine,and the observation group were treated with Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets on the basis of the control group,the 2 groups were treated for a month continuously.The clinical efficacy traditional Chinese medicine score (TCM),and renal function indexes and serum biochemical indexes of 2 groups before and after treatment were compared.Results:After treatment,the total effective rates of observation group was 93.55%,which was obviously higher than that 74.19% in control group (P<0.05):Compared with before treatment,TCM scores of fatigue,dry mouth,night sweats,edema,proteinuria and hematuria,the levels of serum,serum creatinine (Scr),blood urea nitrogen (BUN),tumor necrosis factor-α(TNF-α),total cholesterol (TC),triacylglycerol (TG) and urinary albumin excretion rate (UAER) of 2 groups decreased obviously (P<0.05),and the observation group was obviously lower than the control group (P<0.05).The glomerular filtration rate (GFR) and serum albumin (ALB) of 2 groups increased obviously after treatment,and observation group was obviously higher than control group (P<0.05).Conclusion:Shenyan Kangfu tablets combined with tripterygium polyglycoside tablets in the treatment of MsPGN can improve the TCM scores and renal function,and improve the serum biochemical indicators that the clinical efficacy is outstanding.