益气活血方联合三联疗法对气虚血瘀型慢性萎缩性胃炎患者炎性反应和血液流变学的影响

Effects of Yiqi Huoxue Prescription Combined with Triple Therapy on Inflammatory Reaction and Hemorheology in Patients with Qi deficiency and Blood Stasis Type Chronic Atrophic Gastritis

目的:探究益气活血方联合三联疗法对气虚血瘀型慢性萎缩性胃炎(CAG)患者炎性反应和血液流变学的影响。方法:选取2016年1月至2017年12月新乡市中心医院收治的气虚血瘀型CAG患者160例纳入研究。按照随机数字表法分为对照组和观察组,每组80例,对照组予以奥美拉唑、阿莫西林以及克拉霉素三联疗法治疗,观察组在此基础上联用益气活血方,2组均治疗8周,比较2组临床疗效、临床症状的改善情况以及不良反应发生情况,比较治疗前和治疗8周后炎性反应递质、血液流变学。结果:观察组的总有效率为95. 00%,明显高于对照组的85. 00%(P <0. 05)。观察组痞满、脘痛、纳呆、嗳气、乏力、上腹压痛及舌象的总改善率均高于对照组(P <0. 05)。治疗8周后观察组的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、表皮生长因子(EGF)、白细胞介素-32(IL-32)及转化生长因子-β1(TGF-β1)水平均明显低于对照组,血浆黏度、全血黏度、红细胞沉降率及纤维蛋白原水平也明显低于对照组(P <0. 05)。观察组的不良反应总发生率为5. 00%,与对照组的8. 75%比较,差异无统计学意义(P> 0. 05)。结论:气虚血瘀型CAG患者采用益气活血方联合三联疗法治疗安全有效,并对其机体的炎性反应和血液流变学也有较好的改善作用,有助于更好地促进患者的康复。

Objective:To study the effects of Yiqi Huoxue Prescription combined with triple therapy on inflammatory reaction and hemorheology in patients with Qi deficiency and blood stasis type chronic atrophic gastritis (CAG).Methods:A total of 160 patients with Qi deficiency and blood stasis type CAG who were treated in Xinxiang Central Hospital from January 2016 to December 2017 were included in the study.According to the random number table method,the patients were divided into the observation group and the control group with 80 cases in each group.The control group was treated with triple therapy of omeprazole,amoxicillin and clarithromycin.The patients in the observation group were combined with Yiqi Huoxue prescription on the basis of control group,and two groups were treated for 8 weeks.The clinical efficacy,the improvement of clinical symptoms and the incidence of adverse reactions were compared between the two groups,and the levels of inflammatory factors and hemorheology were compared before treatment and 8 weeks after treatment.Results:The total effective rate of the observation group was 95.00%,which was significantly higher than the control group of 85.00%(P<0.05).The total improvement rate of fullness,stomachache,aversion,belching,fatigue,upper abdominal tenderness and tongue appearance in the observation group were all higher than those of the control group (P<0.05).After treatment,the levels of interleukin-6 (IL-6),tumor necrosis factor-α(TNF-α),epidermal growth factor (EGF),interleukin-32 (IL-32) and transforming growth factor-β1 (TGF-β1) in the observation group were significantly lower than the control group,and the levels of plasma viscosity,whole blood viscosity,erythrocyte sedimentation rate and fibrinogen were also significantly lower than those in the control group (P<0.05).The total incidence of adverse reactions in the observation group was 5.00%,compared with 8.75% in the control group,and the difference was no statistical significance (P>0.05).Conclusion:The treatment of patients with qi deficiency and blood stasis type of CAG with Yiqi Huoxue Prescription combined with triple therapy is safe and effective.It can also improve the inflammatory reaction and hemorheology of the body and help to improve the recovery of patients.