紫杉醇联合卡铂对复发上皮性卵巢癌妇女血清HE4、HK10及T细胞亚群水平的影响

Effects of paclitaxel and carboplatin on serum levels of HE4,HK10 and T cells in women with recurrent epithelial ovarian cancer

目的研究紫杉醇联合卡铂对复发上皮性卵巢癌妇女血清HE4、HK10及T细胞亚群水平的影响。方法选取复发上皮性卵巢癌患者80例,随机分为对照组和研究组,每组40例。对照组患者在进行常规治疗的基础上,单独使用卡铂进行治疗;研究组患者在进行常规治疗的基础上,联合使用紫杉醇和卡铂进行治疗,化疗方案6周后分析两组患者疗效、血清HE4、HK10及T细胞亚群水平以及不良反应之间的差异。结果经过治疗,研究组患者的总有效率明显高于对照组(P<0.05);分析患者的肿瘤标记物发现,研究组患者的HE4、HK10水平显著低于对照组(P<0.05),T细胞亚群水平中CD3+、CD4+、CD8+、CD4+/CD8+显著高于对照组(P<0.05);两组患者的不良反应无明显统计学意义(P>0.05)。结论紫杉醇和卡铂的联合使用效果显著,能明显降低患者血清HE4以及HK10水平,同时可以增强机体的免疫功能,治疗方案安全性较好。

Objective To observe the effects of paclitaxel and carboplatin on serum levels of HE4,HK10 and T cells in women with recurrent epithelial ovarian cancer.Methods 80 patients with severe acute pancreatitis in our hospital were divided into control group and study group randomly,40 cases in each group,patients in the control group,carboplatin therapy alone was used on the basis of the conventional treatment.The difference between the level of efficacy,two groups of patients with serum HE4,HK10 and T cell subsets and adverse reactions were observed after 6 weeks of chemotherapy.Result After treatment,the total effective rate of the patients in the study group was significantly higher than that of the control group(P<0.05).Analysis of tumor markers in patients,the level of HE4 and HK10 in the study group was significantly lower than that of the control group(P<0.05).The analysis of the immune function of the patients,the CD3^+level of T cell subsets,CD4^+,CD8^+,CD4^+/CD8^+)was significantly higher than the control group(P<0.05).The security analysis point of view,the differences between two groups of patients with adverse reaction there were no statistical significantly differences(P<0.05).Conclusion The combined use of paclitaxel and carboplatin is effective.It has a significant decrease in serum HE4 and HK10 and has a significant effect on improving the immune function of the body.It is safety and worthy of clinical promotion.