动脉瘤样纤维组织细胞瘤4例临床病理观察

Clinicopathological Observation of 4 Cases of Aneurysmal Fibroblastoma

目的探讨动脉瘤样纤维组织细胞瘤的病理学特点、免疫表型、诊断及鉴别诊断。方法对4例动脉瘤样纤维组织细胞瘤的石蜡标本行HE及免疫组织化学染色,回顾性分析患者临床资料,随访并复习相关文献,分析其临床表现及病理学特征。结果4例患者中,男2例,女2例,3例位于四肢,1例位于腹部。镜下肿瘤均具有典型皮肤纤维瘤的组织学特征,不规则出血性裂隙、囊腔结构,伴有含铁血黄素沉积。免疫组化显示波形蛋白和CD68阳性,血管标记物均阴性。结论 AFH形态学上有出血性裂隙、囊腔,需与血管肉瘤和血管瘤样纤维组织细胞瘤等恶性肿瘤进行鉴别。

Objective To investigate the pathological features,immunophenotype,diagnosis and differential diagnosis of aneurysmal fibroblastoma.Methods HE and immunohistochemical staining were performed on 4 paraffin-embedded specimens of aneurysmal fibroblastoma.The clinical data of the patients were retrospectively analyzed.The related literatures were followed up and analyzed.The clinical manifestations and pathological features were analyzed.Results Of the 4 patients,2 were male and 2 were female,3 were in the extremities and 1 was in the abdomen.Microscopically,the tumors have the histological features of typical cutaneous fibroids,irregular hemorrhagic fissures,cystic structures,and hemosiderin deposition.Immunohistochemistry showed vimentin and CD68 positive,and vascular markers were negative.Conclusion There is hemorrhagic fissure and cyst in the morphology of AFH.It needs to be differentiated from malignant tumors such as angiosarcoma and angiotumoid fibroblastoma.