男性乳腺癌与女性乳腺癌临床病理学特征对比分析

Comparative analysis of the clinic pathological features of male breast cancer and female breast cancer

目的:探讨男性乳腺癌的临床病理学特征,并与女性乳腺癌的临床病理学特征进行对比分析。方法:收集2005年1月至2017年12月经病理学确诊的27例男性乳腺癌的临床病理资料,同时选取2017年全部女性乳腺癌655例进行比较分析。结果:与女性乳腺癌的临床病理学特征相比,男性乳腺癌的发病年龄偏大,雌激素受体、孕激素受体表现为高阳性率(P <0.05),且P53低表达(P <0.05);男性乳腺癌的分子亚型主要为Luminal B型,各亚型所占的比例与女性乳腺癌差异有统计学意义(P <0.05)。结论:男性乳腺癌与女性乳腺癌在临床病理学特征的显著性差别,表明两者在生物学行为上可能不全相同,同女性乳腺癌一样,男性乳腺癌的早发现、早诊断对早治疗及改善预后具有重要意义。

Objectives:To investigate the clinical pathological features for male breast cancer,and compare them with female breast cancer.Methods:27 cases of MBC from January 2005 to December 2017 diagnosed by pathological examination were retrospectively reviewed,and 655 cases of female breast cancer in 2017 were selected for comparative analysis.Results:Compared with female breast cancer,male breast cancer tend to develop at an older age(P<0.05),with higher estrogen receptor(ER),progesterone receptor(PR)positive expression rate(P<0.05),meanwhile and lower P53 positive expression rate(P<0.05);Luminal B is the main molecular subtype of male breast cancer,and the proportion of various subtypes is quite different from that of female breast cancer(P<0.05).Conclusions:Male breast cancer and female breast cancer on the clinical features are not all the same,showing that they may have different in biological behaviors.The importance of early discovery and early diagnosis for early treatment and prognosis improvement in men is just like breast cancer in women.