抑郁症患者血清25(OH)D_3水平与HAMD评分的关系

Relationship between serum 25(OH)D_3 level and HAMD score in patients with depression

目的探讨抑郁症患者血清25(OH)D_3水平与HAMD评分的关系。方法选择2010年1月～2018年3月在我院诊断治疗的抑郁症患者25例为观察组,另选择健康志愿者30例为对照组。比较两组血清25(OH)D_3水平,分析抑郁症患者25(OH)D_3水平与HAMD评分的相关性。结果观察组25(OH)D_3水平显著低于对照组,差异有统计学意义(P<0.05)。25例抑郁症患者,其中轻度抑郁症15例,25(OH)D_3水平为(28.3±7.1)ng/mL;中重度抑郁症10例,25(OH)D_3水平(17.5±5.3)ng/mL。两组比较,差异有统计学意义(P<0.05)。抑郁症患者HAMD评分与血清25(OH)D_3水平呈显著负相关的关系(P<0.05)。结论抑郁症患者血清25(OH)D_3水平显著下降,尤其中重度抑郁症患者,下降更显著,患者血清25(OH)D_3水平与HAMD评分呈显著负相关的关系。

Objective To investigate the relationship between serum 25(OH)D3 level and HAMD score in patients with depression.Methods A total of 25 patients with depression diagnosed and treated in our hospital from January 2010 to February 2018 were selected as observation group,and 30 healthy volunteers were selected as control group.Serum 25(OH)D3 levels were compared between the two groups,and the correlation between 25(OH)D3 levels and HAMD scores in patients with depression was analyzed.Results The level of 25(OH)D3 in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).In the 25 patients with depression,15 cases had mild depression,and the 25(OH)D3 level was(28.3±7.1)ng/mL;10 cases had moderate to severe depression,and the 25(OH)D3 level was(17.5±5.3)ng/mL.The difference between the two groups was statistically significant(P<0.05).There was a significant negative correlation between HAMD score and serum 25(OH)D3 level in patients with depression(P<0.05).Conclusion The level of serum 25(OH)D3 in patients with depression is significantly decreased.Especially in patients with moderate to severe depression,the decrease of serum 25(OH)D3 level is more significant.There is a significant negative correlation between serum 25(OH)D3 levels and HAMD scores.