新疆柯尔克孜族人群红细胞ABO、RH系统抗原分布及遗传多态性调查

Antigen Distribution and Genetic Polymorphism of ABO and RH Blood Systems in Kirgiz Population of Xinjiang Uygur Region

目的调查新疆地区柯尔克孜族人群ABO和Rh血型的分布;探索柯尔克孜族特殊Rh表型;并研究其与其他民族、区域的差异。方法以3440例新疆地区柯尔克孜族健康体检者为研究对象,鉴定ABO正反定型和Rh血型,计算出A B O及R h血型的期望值、基因及基因组合体频率、抗原频率,并将本研究的A B O及R h调查值与期望值进行卡方检验后验证Hardy-Weinberg吻合度。结果新疆地区柯尔克孜族人群ABO血型分布特征为B>O>A>AB,AB型血型比例最低(9.19%),A、B、O基因频率分别为0.1922、0.2407、0.5671,ABO血型分布符合Hardy-Weinberg平衡定律;RhD阴性比例为2.18%;未检出表型CCdE-;检出该民族不同Rh血型表型:DCcEE(24例,0.70%)、ccdee(61例,0.78%)、ccdEe(8例,0.23%)、Ccdee(4例,0.12%)、CcdEe(1例,0.03%)、CCdee(1例,0.03%)。结论新疆柯尔克孜族与迁徙至黑龙江的同种同源民族比较,ABO血型分布有明显差异;检出新疆柯尔克孜族人群Rh表型分布与其他民族不同。

Objective To investigate the distribution of ABO and Rh blood groups in the Kirgiz population of Xinjiang region and explore the nationality-featured ABO and Rh phenotypes.Methods A total of 3 440 blood samples of ABO and Rh blood groups were identified in the patients.The value of expectation of ABO and Rh types,genome chimerism frequency and antigen frequency were calculated.The values of survey and expectations were compared for percent of contact area of Hardy-Weinberg.Results The distribution of ABO blood group was B>O>A>AB,and the frequency of AB blood type was the lowest(9.19%)while frequencies of A,B,and O types were 0.192 2,0.240 7,and 0.567 1,respectively,which coincide with the law of genetic equilibrium.The negative rate of Rh type was 2.18%.No phenotype of CCdE was found but various Rh types were seen,including DCcEE(0.70%),ccdee(0.78%),ccdEe(0.23%),Ccdee(0.12%),CcdEe(0.03%),and CCdee(0.03%).Conclusion The Kirgiz nationality in Xinjiang has characteristic genetic frequency of Rh blood group,and has a different distribution of ABO blood group when compared with the Kirgiz population who have migrated to Heilongjiang,the northeast of China.