总胆固醇及肌酐水平检测对急性心肌梗死患者PCI治疗预后的影响

Significance of Total Cholesterol and Creatinine Detection in PCI Prognosis of the Patients with Acute Myocardial Infarction

目的探究总胆固醇及肌酐水平检测对急性心肌梗死患者经皮冠状动脉介入治疗(PCI)预后的影响。方法选取2016年12月～2017年5月本院收治的确诊为急性心肌梗死并行PCI治疗的患者68例为观察对象,所有患者出院后随访6个月,按照随访中是否发生心脏不良事件分为预后良好组(n=41)与预后不良组(n=27),比较两组患者治疗前后外周血总胆固醇及肌酐水平,并采用受试者工作特征曲线(ROC)分析其对治疗预后的评估价值。结果预后不良组患者治疗前后总胆固醇及肌酐水平均明显高于预后良好组的(P <0.05),pearson相关分析显示患者PCI治疗后心脏不良事件发生率与血总胆固醇及肌酐水平呈正相关(r=0.246,r=0.451,P <0.05),ROC曲线分析显示总胆固醇联合肌酐水平检测对急性心梗患者行PCI治疗后出现预后不良的敏感度为81.48%,特异度为85.37%。结论总胆固醇及肌酐水平与患者心血管受损程度相关,联合检测上述指标可作为预估患者预后情况的辅助手段之一。

Objective To investigate the significance of total cholesterol and creatinine in prognosis of percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI)Methods 68 cases of PCI with AMI in the hospital were collected in 2016-2017.All subjects were divided into two groups of favourable(n=41)and unfavourable prognosis(n=2 7)according to the occurrence of adverse cardiac events in the follow-up period.The levels of total cholesterol and creatinine were compared before and after treatments.The ROC curve was used to evaluate the prognostic value of the treatments.Results The levels of total cholesterol and creatinine in patients with unfavourable prognosis were significantly elevated compared to those of unfavourable prognosis(P<0.05).Pearson correlation analysis showed that the incidence of cardiac adverse events following PCI treatments was positively correlated with total cholesterol and creatinine(r=0.2 4 6,r=0.4 5 1,P<0.0 5).ROC curve analysis showed that the detection sensitivity of total cholesterol combined with creatinine in AMI patients after PCI treatments was 81.48%,and the specificity was 85.37%.Conclusion The levels of cholesterol and creatinine are related to the severity of cardiovascular damage,and the combined measurements of total cholesterol and creatinine is useful for prediction of the prognosis of PCI patients with acute myocardial infarction.