血清补体C3和C4检测对自身免疫性肝炎患者病情评估的价值

The Value of Serum Complement C3 and C4 in the Assessment of Disease in Patients with Autoimmune Hepatitis

目的探讨血清补体C3和C4检测在自身免疫性肝炎患者病情评估中的应用价值。方法选取2011年10月～2017年5月本院收治的自身免疫性肝炎患者87例,按病情分为缓解期44例、活动期43例。两组的肝功能生化指标采用全自动生物化学分析仪检测,外周血中的补体C3、C4、Ig A、Ig G、Ig M采用透射比浊法检测,并进行肝脏穿刺病理组织检测。结果自身免疫性肝炎活动期患者ALT、AST、TBIL、DBIL、GGT、ALP和Ig G水平均高于缓解期患者,差异有统计学意义(P <0.05);自身免疫性肝炎活动期患者血清补体C3、C4表达水平均低于缓解期患者,差异有统计学意义(P <0.05);所有患者C3表达水平与AST、TBIL、DBIL水平呈现负相关(P <0.05);所有患者C3表达水平与ALT、GGT、ALP水平的相关性无统计学意义(P>0.05),C4表达水平与ALT、AST、TBIL、DBIL、GGT、ALP水平的相关性无统计学意义(P>0.05)。19例自身免疫性肝炎活动期患者C4表达水平与组织学活动指数(HAI)评分呈现负相关(P <0.05)。结论自身免疫性肝炎活动期患者血清补体C3、C4表达水平明显降低,为临床早诊断、早治疗提供了可靠依据。

Objective To evaluate the value of serum complement C3 and C4 in the diagnosis of autoimmune hepatitis patients.Methods From October 2011 to May 2017,87 patients with autoimmune hepatitis were treated with 44 cases of remission and 43 cases of active.Biochemical indicators of liver function in two groups by automatic biochemistry analyzer for detection of complement C3,C4,IgA,IgG,IgM,by turbidimetry was detected in peripheral blood,and detect liver biopsy.Results The levels of ALT,AST,TBIL,DBIL,GGT,ALP and IgG in patients with autoimmune hepatitis were significantly higher than those in patients with autoimmune hepatitis remission(P<0.0 5).The level of autoimmune hepatitis(P<0.0 5).The expression of C3 in all patients was significantly lower than that in patients with autoimmune hepatitis remission(P<0.05).The expression of C3 in all patients was negatively correlated with AST,TBIL and DBIL(P<0.05).There was no significant correlation between the expression of C3 and the levels of ALT,AST,TBIL,DBIL,GGT and ALP(P>0.05).There was no significant correlation between ALT expression,ALT,ASTG,DBIL,GGT and ALP levels.The expression of C4 in 19 patients with autoimmune hepatitis was negatively correlated with(Histological activity index)HAI score(P<0.0 5).Conclusion The levels of C3 and C4 in serum of patients with autoimmune hepatitis were significantly decreased,which provided a reliable basis for early diagnosis and early treatment.