埃索美拉唑与奥美拉唑治疗胃溃疡的疗效比较

Comparison of the Efficacy of Esomeprazole and Omeprazole in the Treatment of Gastric Ulcer

目的探析胃溃疡经奥美拉唑和埃索美拉唑治疗的效果。方法选取该院接2017年1—12月收的胃溃疡60例患者为研究对象,随机分设研究组和参照组,每组30例。行奥美拉唑治疗参照组,行埃索美拉唑治疗研究组。比较观察经不同药物治疗取得的效果情况。结果 93.33%为研究组患者的临床疗效率,显著高于参照组患者的70.00%(χ~2=5.455,P<0.05);参照组患者的住院时间、溃疡面积缩小50%时间和溃疡完全愈合时间分别为(9.23±3.13)、(5.30±2.03)d和(8.37±2.02)d显著高于研究组的(6.50±1.62)、(3.09±1.42)和(5.50±1.25)d(P<0.05);研究组患者的不良反应率为10.00%,显著低于参照组的36.67%(P<0.05)。结论相比奥美拉唑,对胃溃疡患者实施埃索美拉唑治疗,其治疗效果良好,能使患者病情改善,不适感减轻,缩短住院时间,减少不良反应发生,加快患者机体恢复。

Objective To investigate the effect of omeprazole and esomeprazole in the treatment of gastric ulcer.Methods Sixty patients with gastric ulcer received by the hospital from January to December 2017 were selected as the study subjects.The study group and the reference group were randomly divided into two groups,30 cases in each group.The omeprazole treatment adopted in the referrence group and the esomeprazole treatment in the study group.Compare the effects of different drug treatments.Results 93.33%were clinically effective in the study group,which was significantly higher than 70.00%in the reference group(χ^2=5.455,P<0.05).The length of hospital stay,50%reduction in ulcer area and complete ulcer healing time in the reference group(9.23±3.13),(5.30±2.03)d and(8.37±2.02)d were significantly higher than the study group(6.50±1.62),(3.09±1.42)d and(5.50±1.25)d(P<0.05);The adverse reaction rate of the study group was 10.00%,which was significantly lower than that of the reference group 36.67%(P<0.05).Conclusion Compared with omeprazole,the treatment of patients with gastric ulcer with esomeprazole has a good therapeutic effect,which can improve the patient's condition,reduce the discomfort,shorten the hospitalization time,reduce the occurrence of adverse reactions,and accelerate the recovery of the patient's body.