妥洛特罗贴剂辅助治疗小儿慢性咳嗽的效果

Effect of Tulobuterol Patch in the adjuvant treatment of chronic cough in children

目的研究妥洛特罗贴剂辅助治疗小儿慢性咳嗽的效果及其作用机制。方法选择2014年4月～2017年9月于我院就诊并进行治疗的60例慢性咳嗽患儿,按照随机数字表法分为实验组(n=37)和对照组(n=23)。所有患儿均给予雾化吸入布地奈德悬液进行治疗,实验组在此基础上加用妥洛特罗贴剂。治疗14 d后分析对比两组患儿的治疗效果、症状评分、治疗过程中症状缓解及消失时间、治疗前后嗜酸性粒细胞计数(Eos)及IgE指标和不良反应发生率。结果实验组患儿的治疗总有效率高于对照组(P<0.05);实验组治疗后的症状评分显著低于对照组(P<0.01);实验组患儿的症状缓解时间及消失时间均明显短于对照组(P<0.05);实验组血液中的Eos及血清IgE含量均明显低于对照组(P<0.05);两组患儿的不良反应发生率比较,差异无统计学意义(P>0.05)。结论妥洛特罗贴剂在辅助治疗小儿慢性咳嗽中能够有效降低其血液中Eos、血清炎性因子及IgE含量,还可以快速缓解患儿的咳嗽症状,其疗效也相对较好,值得临床推广应用。

Objective To study the effect and mechanism of Tulobuterol Patch in the adjuvant treatment of chronic cough in children.Methods A total of 60 children with chronic cough treated in our hospital from April 2014 to September 2017 were selected.According to the random number table method,they were divided into the experimental group(n=37)and the control group(n=23).All patients were treated with Nebulized Budesonide Suspension,and the experimental group was supplemented with Tulobuterol Patch on this basis.After treatment for 14 days,the treatment effect,symptom score,symptom relief and disappearance time during treatment,as well as eosinophil count(Eos),serum IgE index and adverse reaction rate before and after treatment were analyzed and compared.Results The total effective rate of treatment in the experimental group was higher than that in the control group(P<0.05).The symptom score in the experimental group was significantly lower than that in the control group(P<0.01).The symptom relief time and disappearance time of the children in the experimental group were significantly shorter than those in the control group(P<0.05).The levels of Eos and serum IgE in the experimental group were significantly lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of chronic cough in children,the Tulobuterol Patch can effectively reduce the Eos,serum inflammatory factor and IgE content in the blood,and can quickly relieve the symptoms of cough in children,and its efficacy is relatively good,which is worthy of clinical promotion and application.