瑞舒伐他汀辅助治疗慢性心力衰竭45例临床分析

CLINICAL ANALYSIS FOR ADJUVANT TREATING CHRONIC HEART FAILURE WITH ROSUVASTATIN OF 45 CASES

目的:研究瑞舒伐他汀辅助治疗慢性心力衰竭对患者心功能、炎性因子、氧化应激指标的影响。方法:90例慢性心力衰竭患者随机分为研究组(45例)和对照组(45例),给予对照组患者常规治疗,在对照组的基础上给予研究组患者瑞舒伐他汀钙片辅助治疗,治疗周期3个月。对比分析两组患者治疗前后心功能指标[左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左心室射血分数(LVEF)和E峰A峰流速比值(E/A值)]、血清炎性因子[超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)]水平和血浆氧化应激指标[过氧化物酶(MPO)、超氧化物歧化酶(SOD)、丙二醛(MDA)的变化情况。结果:研究组治疗后的LVEF、E/A,血浆SOD含量明显高于对照组(P<0.05);研究组治疗后的LVEDD、LVESD,血清hs-CRP、IL-6、TNF-α水平,血浆MPO和MDA含量明显低于对照组(P<0.05)。结论:在常规治疗的基础上加用瑞舒伐他汀辅助治疗慢性心力衰竭的疗效确切,能有效改善患者的心功能,减轻机体的炎性反应和氧化应激反应。

Objective:To study the effects of adjuvant treating chronic heart failure with rosuvastatin on cardiac function,in?ammatory response and oxidative stress.Methods:90 chronic heart failure patients were randomly divided into study group(45 cases)and control group(45 cases).The patients in control group were given routine treatments for 3 months;On the basis of routine treatments,the patients in study group were also given rosuvastatin for 3 months.The cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left ventricular ejection fraction(LVEF)and A E peak velocity ratio(E/A value)],serum in?ammatory factors level[hypersensitive C-reactive protein(hs-CRP),interleukin 6(IL-6),tumor necrosis factor alpha(TNF-α)]and plasma oxidative stress indexes[peroxidase(MPO),superoxide dismutase(SOD),malondialdehyde(MDA)]of patients in 2 groups were compared.Results:After treatment,the LVEF,E/A and SOD of patients in study group were obviously higher than control group(P<0.05);the LVEDD,LVESD,hs-CRP,IL-6,TNF-α,MPO and MDA were obviously lower than control group(P<0.05).Conclusions:Adjuvant treating chronic heart failure with rosuvastatin on the basis of routine treatments can get de?nite curative effects,which can improve the cardiac function,reduce in?ammatory response and oxidative stress effectively.