乙型病毒性肝炎合并发热性感染采用药物综合治疗的效果

Effect of comprehensive drug therapy on hepatitis B complicated with febrile infection

目的分析乙型病毒性肝炎(乙肝)合并发热性感染采用药物综合治疗的效果。方法选择2017年1月至2018年2月于我院就诊的100例乙肝患者为研究对象,根据是否合并发热性感染分为发热组(54例)与非发热组(46例),均给予药物综合治疗。对比两组肝功能受损程度、疗效、炎性因子[白细胞介素-17(IL-17)、降钙素原(PCT)]、肝纤维化指标[层连蛋白(LN)、透明质酸(HA)、前Ⅲ型胶原肽(PCⅢ)、Ⅳ型胶原(Ⅳ-C)]水平。结果非发热组的肝功能显著优于发热组(P<0.05)。两组治疗总有效率比较,差异不具有统计学意义(P>0.05)。治疗前,非发热组IL-17、PCT、LN、HA、PCⅢ及Ⅳ-C水平均显著低于发热组(P<0.05);治疗后,两组IL-17、PCT、LN、HA、PCⅢ及Ⅳ-C水平均显著降低,且非发热组低于发热组(P<0.05)。结论乙肝合并发热性感染可加重肝功能受损程度,给予药物综合治疗效果确切,有助于减轻炎症反应,延缓肝纤维化进程,改善预后。

Objective To analyze the effect of comprehensive drug therapy on hepatitis B complicated with febrile infection.Methods A total of 100 patients with hepatitis B treated in our hospital from January 2017 to February 2018 were selected as research objects.According to whether they had febrile infection,they were divided into febrile group (54 cases) and non-febrile group (46 cases).All patients were given comprehensive drug therapy.The degree of liver function impairment,curative effects,levels of inflammatory factors [interleukin-17 (IL-17),procalcitonin (PCT)],hepatic fibrosis indexes [laminin (LN),hyaluronic acid (HA),procollagen type Ⅲ(PCⅢ),collagen type Ⅳ(Ⅳ-C)] were compared between the two groups.Results The liver function of the non-fever group was significantly better than that of the fever group (P<0.05).There was no significant difference in the total effective rates of treatment between the two groups (P>0.05).Before treatment,the levels of IL-17,PCT,LN,HA,PCⅢ and Ⅳ-C in the non-febrile group were significantly lower than those in the febrile group (P<0.05).After treatment,the levels of IL-17,PCT,LN,HA,PCⅢ and Ⅳ-C in the two groups decreased significantly,and those in the non-febrile group were significantly lower than the febrile group (P<0.05).Conclusion Hepatitis B complicated with febrile infection can aggravate the degree of liver function damage.The comprehensive drug therapy has a definite effect,which is helpful to alleviate inflammation reactions,delay the process of hepatic fibrosis and improve prognosis.