丹参粉针治疗溃疡性结肠炎的效果及其对患者Hcy、炎症因子水平的影响

Effect of Danshen powder injection in the treatment of ulcerative colitis and its effect on the levels of Hcy and inflammatory factors of patients

目的探讨丹参粉针治疗溃疡性结肠炎(UC)的效果及其对患者同型半胱氨酸(Hcy)、炎症因子水平的影响。方法选取2016年12月至2017年9月我院收治的102例UC患者为研究对象,将其随机分为观察组(美沙拉秦+丹参粉针)和对照组(美沙拉秦),各51例。比较两组临床疗效、治疗前、后血清TNF-α、IL-6、IL-8、Hcy水平及不良反应发生情况。结果治疗后,两组患者血清TNF-α、IL-6、IL-8及Hcy水平均明显降低,且观察组显著低于对照组,差异具有统计学意义(P<0.05);观察组的治疗总有效率为94.12%,明显高于对照组的78.43%(P<0.05);两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论丹参粉针治疗UC患者临床效果确切,可显著降低患者的血清TNF-α、IL-6、IL-8及Hcy水平,且安全性高。

Objective To investigate the effect of Danshen powder injection in the treatment of ulcerative colitis and its effect on the levels of Hcy and inflammatory factors of patients.Methods A total of 102 UC patients admitted in our hospital from December 2016 to September 2017 were selected as study objects.They were randomly divided into observation group (mesalazine+Danshen powder injection) and control group (mesalazine),with 51 cases in each group.The clinical efficacy,serum levels of TNF-α,IL-6,IL-8 and Hcy before and after treatment and the incidence of adverse reactions were compared between the two groups.Results After treatment,the serum levels of TNF-α,IL-6,IL-8 and Hcy in the two groups significantly decreased,and those in the observation group were significantly lower than the control group,the differences were statistically significant (P<0.05).The total effective rate of treatment in the observation group was 94.12%,which was significantly higher than 78.43% of the control group (P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion Danshen powder injection has a definite clinical effect in the treatment of UC.It can significantly reduce the serum levels of TNF-α,IL-6,IL-8 and Hcy,and has high safety.