丙泊酚与气体麻醉对老年患者术后认知功能障碍的影响

Effect of propofol and gas anesthesia on postoperative cognitive dysfunction in elderly patients

目的分析丙泊酚与气体麻醉对老年患者术后认知功能障碍的影响。方法将我院收治的70例行手术治疗的老年患者作为研究对象,将其分为对照组(n=35,七氟烷维持麻醉)和研究组(n=35,丙泊酚维持麻醉)。比较两组患者的效果。结果手术后24 h,研究组认知功能评分、S100β蛋白水平优于对照组(P<0.05);研究组麻醉苏醒时间短于对照组(P<0.05);两组患者疼痛评分比较,差异不显著(P>0.05);研究组认知功能障碍发生率低于对照组(P<0.05);两组躁动发生率比较,差异不显著(P>0.05)。结论对行手术治疗的老年患者采用丙泊酚与气体麻醉,均有良好的镇痛效果。丙泊酚对患者神经系统的损伤更小,不仅能减少患者术后认知功能障碍的发生,还能缩短其术后苏醒时间。

Objective To analyze the effect of propofol and gas anesthesia on cognitive dysfunction in elderly patients after operation.Methods Seventy elderly patients who underwent surgical treatment in our hospital were divided into control group (n=35,sevoflurane maintenance anesthesia) and research group (n=35,propofol maintenance anesthesia).The anesthesia effects of the two groups were compared.Results At 24 hours after operation,the cognitive function score and the level of S100β protein in the research group were better than those in the control group (P<0.05).The recovery time of anesthesia in the research group was shorter than that in the control group (P<0.05).There was no significant difference in pain score between the two groups (P>0.05).The incidence of cognitive dysfunction in the research group was lower than that in the control group (P<0.05).There was no significant difference in the incidence of restlessness between the two groups (P>0.05).Conclusion Propofol and gas anesthesia have good analgesic effects for elderly patients undergoing surgical treatment.Propofol has less damage to the nervous system of patients,which can not only reduce the incidence of cognitive impairment after operation,but also shorten the recovery time after operation.