固肾安胎丸联合地屈孕酮治疗复发性自然流产的临床效果

Clinical effect of Gushen Antai pill combined with didrogesterone in the treatment of recurrent spontaneous abortion

目的探讨固肾安胎丸联合地屈孕酮治疗复发性自然流产(RSA)的治疗效果。方法选取2014年1月至2017年1月我院妇科收治的具有RSA病史的患者86例,根据治疗方式的不同将其分为治疗组(43例)和对照组(43例)。对照组孕后口服地屈孕酮和维生素E至孕12周。治疗组孕前口服固肾安胎丸,孕后口服固肾安胎丸、地屈孕酮和维生素E至孕12周。比较两组患者的临床疗效、治疗前、后血清孕酮、β-HCG水平及孕期主要症状和体征发生情况。结果治疗组的治疗总有效率为90.70%,显著高于对照组的74.42%(P<0.05)。治疗后,两组血清孕酮和β-HCG水平均显著升高,且治疗组显著高于对照组(P<0.05)。治疗组患者阴道流血、腰骶酸痛、下腹疼痛或坠胀发生率显著低于对照组(P<0.01)。结论固肾安胎丸联合地屈孕酮治疗RSA可有效提高血清β-HCG和孕酮水平,改善临床症状,值得临床推广应用。

Objective To investigate the therapeutic effect of Gushen Antai pill combined with didrogesterone in the treatment of recurrent spontaneous abortion (RSA).Methods Eighty-six patients with RSA history admitted in gynecology department of our hospital from January 2014 to January 2017 were selected and divided into treatment group (43 cases) and control group (43 cases) according to different treatment methods.The control group received oral desdrogesterone and vitamin E after pregnancy until 12 weeks of gestation.The treatment group accepted oral Gushen Antai pill before pregnancy,and accepted oral Gushen Antai pill,didrogesterone and vitamin E after pregnancy until 12 weeks of gestation.The clinical efficacy,levels of serum progesterone and β-HCG before and after treatment,the incidence of main symptoms and signs during pregnancy were compared between the two groups.Results The total effective rate of treatment in the treatment group was 90.70%,which was significantly higher than 74.42% of the control group (P<0.05).After treatment,the levels of serum progesterone and β-HCG in both groups increased significantly,and those in the treatment group were significantly higher than the control group (P<0.05).The incidences of vaginal bleeding,lumbosacral pain,lower abdominal pain or swelling in the treatment group were significantly lower than those in the control group (P<0.01).Conclusion Gushen Antai pill combined with didrogesterone in the treatment of RSA can effectively improve levels of serum β-HCG and progesterone,improve clinical symptoms,and it is worthy of clinical promotion and application.