摘要
目的:探讨半夏白术天麻方治疗风痰上扰型眩晕的临床疗效。方法:选取风痰上扰证眩晕患者200例为研究对象。采用随机双盲法将以上纳入患者分为对照组和观察组各100例。对照组给予盐酸氟桂利嗪片治疗,观察组在对照组基础上给予自拟半夏白术天麻方治疗。比较两组患者治疗前后中医症候积分变化、TCD相关参数、凝血四项及眩晕障碍评分量表(DHI)、临床疗效及不良反应情况。结果:治疗后,两组中医症候积分均明显降低(P<0.05);观察组治疗后中医症候积分明显低于对照组(P<0.05);观察组总有效率明显高于对照组(P<0.05);治疗后两组LVA、RVA及BA血流速度均明显增高,观察组TCD相关参数均高于对照组(P<0.05)。两组治疗后凝血四项指标均明显改善,观察组比对照组改善更明显(P<0.05)。治疗后两组躯体、情绪及功能评分均明显下降,观察组DHI评分均低于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:自拟半夏白术天麻方可显著降低风痰上扰证型眩晕症患者中医症候积分,临床疗效显著,且用药安全。
Objective:To investigate the clinical efficacy of Banxia Baizhu Tianma prescription in treating vertigo due to wind phlegm disturbance.Methods:200 patients with vertigo due to wind-phlegm disturbance syndrome.The patients were divided into control group and observation group by random double blind method,100 cases in each group.The control group was treated with flunarizine hydrochloride tablets,while the observation group was treated with self-made Banxia Baizhu Tianma decoction on the basis of the control group.The changes of TCM syndrome score,TCD related parameters,coagulation and vertigo disorder score(DHI),clinical efficacy and adverse reactions were compared between the two groups before and after treatment.Results:There was no significant difference in the scores of TCM symptoms between the two groups before treatment(P﹥0.05);after treatment,the scores of TCM symptoms in both groups were significantly reduced(P﹤0.05);after treatment,the scores of TCM symptoms in the observation group were significantly lower than those in the control group(P﹤0.05);the total effective rate in the observation group was 92.00%(92/100)significantly higher than that in the control group.After treatment,the blood flow velocity of LVA,RVA and BA in both groups increased significantly,and the TCD related parameters in observation group were higher than those in control group(P﹤0.05).After treatment,the four indexes of coagulation in both groups were significantly improved,and the improvement in the observation group was more obvious than that in the control group(P﹤0.05).After treatment,the scores of body,emotion and function of the two groups were significantly decreased,and the DHI scores of the observation group were lower than those of the control group(P﹤0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P﹥0.05).Conclusion:Banxia Baizhu Tianma prescription can significantly reduce the syndrome score of vertigo patients with wind-phlegm disturbance syndrome,and the clinical effect is significant,and drug safety.
作者
孟占鹏
李柱
倪进军
郭子华
张天华
MENG Zhanpeng;LI Zhu;NI Jinjun(Department of Brain Disease,Kaifeng TCM Hospital in Henan Province,Kaifeng 475000)
出处
《陕西中医》
2019年第2期185-187,191,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
河南省科技攻关计划项目(132102310464)