肉芽肿性小叶乳腺炎临床病理分析

Clinicopathological Analysis of Granulomatous Lobular Mastitis

目的分析临床肉芽肿性小叶乳腺炎的病理特点。方法以2015年7月—2018年6月该院8例经病理诊断为肉芽肿性小叶乳腺炎患者为对象,分析患者病理特点。结果巨检显示患者平均肿块直径(6.75±1.06)cm,有5例为灰黄灰红相间,2例为黄色颗粒状,1例为囊实性。镜检结果显示7例患者病变在小叶内局限存在,1例患者病变造成小叶外受累;5例患者病变小叶末梢导管全部消失,3例患者存在腺泡残留;2例患者形成小脓肿,1例出现嗜酸性粒细胞浸润;1例同时出现导管扩张症,1例出现纤维腺瘤,1例出现导管内乳头状瘤。8例患者中有6例接受术中冰冻,没有恶性确诊患者,术后均进行石蜡切片诊断为肉芽肿小叶性乳腺炎。随访期间没有复发的患者。结论病理诊断是临床针对肉芽肿性小叶乳腺炎确诊的重要方法,应该注重肉芽肿性小叶乳腺炎的病理检查,以保证诊断准确率。

Objective To analyze the pathological features of clinical granulomatous lobular mastitis.Methods Eight patients with granulomatous lobular mastitis diagnosed by pathology from July 2015 to June 2018 were enrolled in this study.Results The giant examination showed the average tumor diameter (6.75±1.06)cm.There were 5 cases of grayish yellowish gray and red,2 cases of yellow granular and 1 cases of cystic solid.The results of microscopic examination showed that the lesions of 7 patients were confined in the lobule,and one patient suffered from extralobular involvement.In 5 patients,the peripheral lobular ducts disappeared,3 patients had acinar residual; 2 patients developed small abscess,1 case Eosinophilic infiltration occurred; 1 case of ductal dilatation occurred simultaneously,1 case of fibroadenomas appeared,and 1 case of intraductal papilloma.6 of the 8 patients underwent intraoperative freezing,and no malignant confirmed patients were diagnosed with granuloma lobular mastitis after paraffin sectioning.There were no relapsed patients during the follow-up period.Conclusion Pathological diagnosis is an important method for the diagnosis of granulomatous lobular mastitis.It should pay attention to the pathological examination of granulomatous lobular mastitis to ensure the accuracy of diagnosis.