丁苯酞注射液联合依达拉奉治疗急性脑梗死的疗效及安全性评价

Efficacy and Safety of Butylphthalide Injection Combined with Edaravone in the Treatment of Acute Cerebral Infarction

目的探讨丁苯酞注射液联合依达拉奉治疗急性脑梗死的疗效及安全性。方法方便选取2015年1月—2017年1月期间该院收治的80例急性脑梗死患者作为研究对象,按随机数表法分为联合组(n=40)与对照组(n=40)。对照组单纯给予依达拉奉治疗,联合组给予丁苯酞注射液联合依达拉奉治疗,比较两组治疗效果、神经功能、自理能力及不良反应发生≥情况。结果联合组治疗总有效率为82.50%,较对照组57.50%更高,两组比较差异有统计学意义(χ2=5.952,P<0.05);两组NIHSS评分均明显下降,且联合组为(6.45±1.37)分,下降幅度更大,而两组Barthel指数均明显上升,且联合组为(52.35±5.12)分,上升幅度更大,上述差异有统计学意义(t=7.374、7.324,P<0.05)。结论对急性脑梗死患者采用依达拉奉联合丁苯酞注射液治疗,疗效确切,且不良反应少,可有效促进患者神经功能恢复,改善生活自理能力,具有临床推广意义。

Objective To investigate the efficacy and safety of butylphthalide injection combined with edaravone in the treatment of acute cerebral infarction.Methods 80 patients with acute cerebral infarction admitted to the hospital from January 2015 to January 2017 were convenient selected and enrolled in the study.They were divided into the combination group (n=40) and the control group (n=40) according to the random number table method.The control group was treated with edaravone alone,and the combination group was given butylphthalide injection combined with edaravone.The treatment effect,neurological function,self-care ability and adverse reactions occurred in the two groups.Results The total effective rate was 82.50% in the combined group,which was higher than that in the control group (57.50%).The difference between the two groups was statistically significant (χ^2=5.952,P<0.05).The NIHSS scores of both groups were significantly decreased,and the combined group was (6.45±1.37)points,the decline was larger,and the Barthel index of both groups increased significantly,and the combined group was (52.35±5.12)points,greatly increased,the above differences were statistically significant (t=7.374,7.324,P<0.05).Conclusion For patients with acute cerebral infarction,edaravone combined with butylphthalide injection is effective and has few adverse reactions.It can effectively promote the recovery of neurological function and improve self-care ability.It has clinical significance.