γ-干扰素释放试验(IGRA)在结核性胸膜炎的诊断价值

Diagnostic Value of γ-interferon Release Test(IGRA) in Tuberculous Pleurisy

目的研究γ-干扰素释放试验(IGRA)在结核性胸膜炎的诊断价值。方法入选患者为方便选取2014年4月—2018年4月福建医科大学附属泉州第一医院呼吸内科有行IGRA检测的胸腔镜检查病例。分析IGRA在这些患者诊断结核性胸膜炎的敏感度、特异度、阳性似然比、阴性似然比、Kappa值、ROC曲线面积。结果总共入选187例,104例(55.6%)为结核性胸膜炎患者,130例(69.5%)为男性患者,平均年龄53.1岁(18～88岁)。IGRA诊断结核性胸膜炎的灵敏度86.5%、特异性81.9%、阳性似然比4.78、阴性似然比0.16、Kappa值0.685、ROC曲线面积0.843(0.782～0.904,P<0.001)。结论 IGRA在诊断结核性胸膜炎有很高的价值。

Objective To study the diagnostic value of γ-interferon release test (IGRA) in tuberculous pleurisy.Methods The patients who were enrolled in the Department of Respiratory Medicine of Quanzhou First Hospital affiliated to Fujian Medical University from January 2014 to January 2018 had a thoracoscopic examination.The sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,Kappa value,and ROC curve area of IGRA in the diagnosis of tuberculous pleurisy were analyzed.Results A total of 187 patients were enrolled,104 cases(55.6%) were tuberculous pleurisy patients,and 130 cases(69.5%) were male patients with an average age of 53.1 years (18-88 years).IGRA diagnosis of tuberculous pleurisy was 86.5%,specificity 81.9%,positive likelihood ratio 4.78,negative likelihood ratio 0.16,Kappa value 0.685,ROC curve area 0.843 (0.782-0.904,P<0.001).Conclusion IGRA is of great value in the diagnosis of tuberculous pleurisy.