妊娠合并HIV感染母婴阻断及妊娠结局的研究

Pregnancy Outcomes and Maternal Infant Block of Pregnancy Complicated with HIV Infection

目的探讨妊娠合并HIV感染母婴阻断效果及妊娠结局。方法选取2015年1月-2017年1月我院收治的89例妊娠合并HIV感染孕妇,根据孕妇开始三联高效抗反转录病毒药物治疗(HAART)时间,分为孕期治疗组(48例)和产前治疗组(41例),观察两组妊娠结局及阻断效果。结果孕期治疗组早产比例为4. 17%,明显低于产前治疗组(P<0.05);两组新生儿窒息发生率和新生儿出生体质量比较差异无统计学意义(P>0.05);孕期治疗组剖宫产比例为60.42%,明显低于产前治疗组的90.24%,差异有统计学意义(P<0.05);孕期治疗组婴儿HIV感染率为0.00%,明显低于产前治疗组的10.26%,差异有统计学意义(P<0.05)。结论孕期给予HAART等综合干预措施,能有效预防母婴传播,且对胎儿生长发育无明显不良影响。

Objective To investigate the pregnancy outcomes and maternal infant block of pregnancy complicated with HIV infection.Methods Eighty-nine pregnant women with HIV infection treated in our hospital between January 2015 and January 2017 were selected as the subjects.According to the start time of triple antiretroviral therapy(HAART)for pregnant women,48 cases were assigned to the pregnancy treatment group and another 41 cases served as the prenatal treatment group.Both groups were given comprehensive interventions,such as safe delivery and artificial feeding.The pregnancy outcomes and blocking effect were compared between the two groups.Results The percentage of premature delivery in the pregnancy treatment group was 4.17%,which was significantly lower than that in the prenatal treatment group(P<0.05).There was no significant difference in the incidence of neonatal asphyxia or neonatal birth weight between the two groups(P>0.05).The percentage of cesarean section in the pregnancy treatment group was 60.42%,which was significantly lower than that of the prenatal treatment group(90.24%),and the difference was statistically significant(P<0.05).The HIV infection rate was 0.00%in the pregnancy treatment group,significantly lower than that in the prenatal treatment group(9.76%),and the difference was of statistical significance(P<0.05).Conclusion HAART and other comprehensive interventions during pregnancy can effectively prevent mother to child transmission,and there is no obvious adverse effect on fetal growth and development.