硝苯地平联合缬沙坦胶囊治疗老年冠心病合并高血压的效果观察

Clinical efficacy and safety of nifedipine combined with valsartan in treating coronary heart disease complicated with hypertension in elderly patients

目的探讨硝苯地平联合缬沙坦胶囊治疗老年冠心病合并高血压的临床效果及安全性。方法将108例老年冠心病合并高血压患者随机分为两组,各54例。两组均接受硝苯地平治疗,观察组同时联合应用缬沙坦胶囊治疗。比较两组治疗前后的血压、血脂、心功能指标变化及不良反应发生情况,并评价临床疗效。结果治疗后,两组患者血压、血脂均明显低于治疗前(P<0.01),且观察组各项指标明显优于对照组(P<0.01);两组左室舒张末期内径明显减小(P<0.01),左室射血分数明显升高(P<0.01),且观察组改变幅度明显优于对照组(P<0.01);观察组临床疗效优于对照组(P<0.05);两组不良反应发生率比较无统计学差异(P>0.05)。结论硝苯地平联合缬沙坦胶囊可有效控制老年冠心病合并高血压患者的动脉血压水平,降低血脂,改善心脏功能,安全可行。

Objective To investigate the clinical efficacy and safety of nifedipine and valsartan capsules in therapy for coronary heart disease complicated with hypertension in elderly patients.Methods A total of 108 elderly patients with coronary heart disease complicating hypertension were randomly divided into observation group and control group,with 54 patients in each group.All of the patients were administrated with nifedipine,meanwhile observation group received valsartan capsule.The datum,included the blood pressure,blood lipid level and cardiac function of the two groups,were compared before and after treatment to evaluate the clinical curative effect.The adverse reactions in the two groups were observed.Results After treatment,the diastolic blood pressure and systolic blood pressure were significantly decreased in both groups.All the determined parameters including the levels of TG,TC,LDL-C and blood pressure were significantly decreased(P<0.01).The left ventricular end diastolic diameter of the two groups decreased significantly,and the left ventricular ejection fraction increased significantly,compared with pre-treatment(P<0.01).Moreover the observation group achieved a much more changed degree in the cardiac-functional parameters than the control group(P<0.01).The clinical effect of the observation group was obviously better than that of the control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Nifedipine plus valsartan capsules could effectively control the blood pressure of elderly patients with coronary heart disease complicating hypertension,reduce their blood lipid levels and improve cardiac function,with a good safety and feasible.