高浓度使用BMP-2的副作用及应对措施研究进展

Related side effects and prospect of BMP-2 in high dose application

骨形态发生蛋白-2(Bone morphogenetic protein-2, BMP-2),是目前美国食品药物管理局(Food and Drug Administration, FDA)批准应用于临床的唯一一种具有骨诱导作用的生长因子,自1965年被发现以来,因其具有骨形成作用,被广泛应用于临床骨缺损治疗。由于缺乏明确的浓度与疗效的关系,为了取得良好的治疗效果,临床上一般采取较高浓度应用,许多与浓度相关的副作用逐渐显现出来。本文主要描述BMP-2在高浓度应用时所导致的副作用,并提出一些可能会减轻副作用的解决方式,希望有更多的研究能明确BMP-2浓度和副作用之间的关系,以此来指导BMP-2的临床应用。

Bone morphogenetic protein-2(BMP-2)is the only growth factor that has been approved by FDA in clinical application at present.Since its discovery in 1965,it has been widely used in various clinical treatments,because it can promote bone formation.Due to the lack of a clear relationship between concentration and efficacy,in order to achieve good therapeutic effects,high concentrations are generally used in clinical use.Then many concentration related side effects are gradually discovered.This review mainly describes the side effects caused by the application of bmp-2 in high concentration,and puts forward some solutions that may reduce side effects.It is hoped that more studies can be used to determine the relationship between the concentration and side effects of BMP-2,and to guide the clinical application of BMP-2.