定量评估PD-1多态性rs10204525与中国人上消化道癌症风险的相关性分析

Quantitative assessment of correction between programmed cell death-1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in Chinese population

目的系统评估PD-1多态性rs10204525和中国人上消化道癌症(UGIC)风险的相关性。方法通过计算机检索PubMed、MEDLINE和中国知网等数据库,共纳入4项研究(2536例UGIC病例和3491例对照人群),应用Stata统计包12.0进行荟萃分析,采用95%置信区间(CI)的合并的比值比(OR)评价PD-1多态性rs10204525与中国人UGIC风险的相关性。结果荟萃分析显示:rs10204525在纯合子(GG vs AA:OR=0.81,95%CI=0.58～1.15,P=0.236)、杂合子(AG vs AA:OR=0.97,95%CI=0.87～1.08,P=0.523)、显性(AG+GG vs AA:OR=0.95,95%CI=0.86～1.05,P=0.333)、隐性(GG vs AG+AA:OR=0.82,95%CI=0.58～1.16,P=0.263)和等位(T vs C:OR=0.95,95%CI=0.88～1.03,P=0.211)基因模型中,与中国人UGIC风险没有相关性。结论 PD-1的多态性rs10204525与中国人UGIC风险没有显著相关性,这个结论在纯合子、杂合子、显性、隐性和等位基因模型中均成立。

Objective To assess the association between the programmed cell death-1(PD-1)polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population.Methods We searched PubMed,MEDLINE,and CNKI databases and retrieved studies(2536 cases and 3491 controls)on the association of PD-1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population.Meta-analysis was performed with Stata statistical package 12.0,with 95%confidence intervals and odds ratios calculated.Results Meta-analysis of all the included clinical trials showed that there was no significant association between the PD-1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population in all the genetic models[homozygous(GG vs AA:OR=0.81,95%CI=0.58~1.15,P=0.236);heterozygous(AG vs AA:OR=0.97,95%CI=0.87~1.08,P=0.523);dominant(AG+GG vs AA:OR=0.95,95%CI=0.86~1.05,P=0.333);recessive(GG vs AG+AA:OR=0.82,95%CI=0.58~1.16,P=0.263);and allele(T vs C:OR=0.95,95%CI=0.88~1.03,P=0.211)].Conclusion There was no significant association between the PD-1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population.