关于卒中后抑郁发病机制的研究新进展

Research progress on the pathogenesis of post-stroke depression

卒中后抑郁是脑卒中后常见的并发症之一,发病率高,其发病机制复杂多变,国内外学者主要认同生物学机制和社会与心理学机制两种学说,生物学因素包括神经递质、炎性细胞因子、病灶部位、同型半胱氨酸、基因突变、神经生长因子等,均与卒中后抑郁的发生密切相关。社会与心理学因素包括人口学因素、失眠、社会支持系统、家庭关系、生活方式以及生活不良事件等,可影响卒中后抑郁的发生与发展。中医对脏腑、气血阴阳病因病机的阐述也与卒中后抑郁的发生密切相关。但卒中后抑郁的形成机制目前尚无明确结论,人们仍需进一步研究相关因素对于疾病发生的作用与联系。

Post-stroke depression is one of the common complications after stroke.The incidence is high and its pathogenesis is complex and changeable.Scholars at home and abroad mainly believe that there are two theories:biological mechanism and social psychological mechanism.Biological mechanism includes neurotransmitter,inflammatory cytokines,lesion site,homocysteine,gene mutation,nerve growth factors,which is correlated to the post-stroke depression.Social and psychological factors,including demographic factors,insomnia,social support,family relations,way of life and adverse life events,all can affect the occurrence and development of post-stroke depression.The explanation of TCM etiology and pathogenesis is also closely related to the occurrence of post-stroke depression.However,the formation mechanism of post-stroke depression has not yet been clearly concluded.People still need to further study the role and relationship between related factors and disease occurrence.