硝苯地平与硫酸镁治疗早产的临床效果比较

Clinical-efficacy comparison of Nifedipine and Magnesium Sulfate in the treatment of preterm labor

目的分析硫酸镁与硝苯地平治疗早产的临床效果、母婴结局及不良事件。方法回顾性分析2016年2月～2017年3月四川省宜宾市第一人民医院接收的98例先兆性早产孕妇资料,依据医治方案不同可分成两组,将行硝苯地平医治的49例患者设为研究组,行硫酸镁医治的49例患者设为对照组,对比两组临床疗效、母婴结局及不良反应状况。结果研究组孕龄延长≥7 d、孕龄延长≥2 d、保胎成功者占比高于对照组,显效时间短于对照组,不良反应总发生率低于对照组,差异均有统计学意义(P <0.05);两组新生儿体重、Apgar评分、分娩孕龄、初次用药后宫缩抑制的时间等母婴结局对比差异无统计学意义(P> 0.05)。结论先兆早产孕妇行硝苯地平医治可提高保胎成功率,延长孕龄,而且药物不良反应发生率较低,具一定临床应用与研究价值。

Objective To analyze clinical effects,maternal and infant outcomes and adverse events of magnesium sulfate and Nifedipine on premature delivery.Methods Clinical data of 98 preterm pregnant women from March 2017 to February 2016 in the First People′s Hospital of Yibin City in Sichuan Province were retrospectively analyzed,and they were divided into two groups according to the treatment scheme,49 patients treated with Nifedipine were set up as the study group,49 patients treated with Magnesium Sulfate were set up as the control group.The clinical curative effect,the maternal and infant outcome and the adverse reaction of the two groups were compared.Results In the study group,the proportion of pregnant women whose duration of gestational age longer than 7 d,gestational age longer than 2 d,and the success rate of fetus preservation were higher than those of control group,and the effective time was shorter than that of the control group,the total incidence of adverse reactions was lower than that of the control group,the differences were statistically significant(P﹤0.05).There was no statistically difference in newborn weight,Apgar score,pregnancy week,and the time of uterine contraction after the first drug use between the two groups(P﹥0.05).Conclusion Treatment with Nifedipine for preterm pregnant women can improve the success rate of pregnancy preservation and prolong the gestational weeks,and the incidence of adverse reactions of drug is low,with a certain clinical application and research value.