脊髓损伤大鼠模型造模方式选择的网状Meta分析

Methods for establishing rat models of spinal cord injury: a meta-analysis

背景:研究脊髓损伤的病理生理、解剖结构等的改变,其前提条件是必须建立一个安全有效且临床相似度高的脊髓损伤大鼠模型。随着研究的进展,基于不同目的各种相关的造模方式层出不穷,对后来的研究者在造模方式的选择难免造成些许干扰。目的:运用网状Meta分析的方法,比较脊髓损伤挫伤型、压迫型、缺血损伤型、横断型各造模方式的有效性和死亡率的排序,为脊髓损伤大鼠模型的造模方式提供有力证据。方法:通过检索截止时间为2018-03-11包括Pub Med、中国知网、重庆维普,万方4个数据库所有关于脊髓损伤造模方式的文献,对文献进行筛选,提取最终纳入文献数据,运用Stata、Winbug软件进行网状分析,得出排序结果。结果与结论:最终17篇文献纳入研究,共506只SpragueDawley(SD)大鼠,脊髓损伤造模方式有效性排序:横断型>挫伤型>压迫型>缺血损伤型;造模方式死亡率从高到低的排序:横断型>挫伤型>压迫型>缺血损伤型。

BACKGROUND:A safe and effective spinal cord injury rat model with high clinical similarity is important for the studies on changes in the pathophysiology and anatomy of spinal cord injury.There are various modeling methods,so choosing which one still remains controversial.OBJECTIVE:To compare the efficacy and mortality of various models of spinal cord injury contusion type,compression type,ischemic injury type,and transverse type using a meta-analysis so as to provide evidence for establishing rat models of spinal cord injury.METHODS:Databases of PubMed,CNKI,VIP and WanFang were searched for the literature concerning spinal cord injury modeling methods published before March 11,2018.The literature screening and data extraction were conducted.Mesh analysis was performed on Stata and Winbug software to obtain the efficacy results.RESULTS AND CONCLUSION:A total of 17 eligible articles were included,involving 506 Sprague-Dawley rats.The order of the effectiveness of spinal cord injury model was as follows:transverse>contusion>compression>ischemic injury.The order of mortality was as follows:transverse>contusion>compression>ischemic injury.