Toll样受体2基因Arg753Gln和CD14启动子-159C/T多态性与肺炎链球菌病易感性的Meta分析

Meta analysis of TLR2 Arg753Gln and CD14-159C/T polymorphisms and susceptibility to Streptococcus pneumoniae disease

目的评价Toll样受体2基因Arg753Gln和CD14启动子-159C/T多态性与肺炎链球菌病易感性的相关性。方法检索PubMed、Cohrance、Embase、CNKI、维普、万方等数据平台,检索文献时间限定为从建库到2017年6月1日。搜寻符合纳入和排除条件的随机对照研究,RevMan 5.3软件进行Meta分析。结果纳入TLR2有关论文3篇,样本量总计为951例;纳入CD14相关研究2篇,样本量总计为674例。Meta分析未见TLR2基因Arg753Gln多态性和CD14-159C/T多态性与肺炎链球菌病易感性相关(显性等位基因vs.隐性等位基因:OR=0.76,95%CI=0.40～1.46,P=0.41;显性基因型vs.隐性基因型时,OR=0.70,95%CI=0.34～1.44,P=0.33)。结论未见TLR2基因Arg753Gln和CD14-159C/T多态性与肺炎链球菌病易感性相关。

Objective To investigate the association between TLR2 Arg753Gln and CD14-159C/T polymorphisms and Streptococcus pneumoniae disease.Methods Pubmed,embase,Cohrance,CNKI,VIP,Wanfang Data were searched to get related clinical controlled trials.The time limit for retrieving studies was until June 1,2017.Meta-analysis was conducted by Revman 5.3 software.Results Three TLR2 related papers were included,with a total sample size of 951 cases.Two CD14 related studies were included,with a total sample size of 674 cases.Meta-analysis showed no correlation between Arg753Gln polymorphism of TLR2 gene and CD14-159C/T polymorphism and susceptibility to Streptococcus pneumoniae disease(dominant allele vs.recessive alleles:OR=0.76,95%CI=0.40-1.46,P=0.41;dominant genotype vs.recessive genotype:OR=0.70,95%CI=0.34-1.44,P=0.33).Conclusion No significant differences between TLR2 Arg753Gln and CD14-159C/T polymorphisms and Streptococcus pneumoniae disease were found in the meta-analysis.