自拟糖痹康治疗气虚血瘀型糖尿病周围神经病变的临床效果

Clinical effect of Self-formulated prescription Tangbikang in the treatment of qi deficiency and blood stasis in diabetic peripheral neuropathy

目的探究自拟糖痹康治疗气虚血瘀型糖尿病周围神经病变的临床效果。方法选取2016年10月～2017年3月我院收治的80例糖尿病周围神经病变患者作为研究对象,采用随机数字表法将患者分为两组,每组各40例。对照组采用基础治疗联合甲钴胺口服治疗,观察组在对照组基础上伍用自拟糖痹康治疗,两组均治疗8周为1个疗程。比较两组患者的临床疗效、TCSS评分、神经传导速度的变化、血流变指标的变化。结果观察组患者的治疗总有效率为87.5%,高于对照组的67.5%,差异有统计学意义(P<0.05);治疗后两组患者多伦多临床评分系统(TCSS)评分低于治疗前,且观察组患者的TCSS评分低于对照组,差异均有统计学意义(P<0.05);两组患者治疗后的正中神经和腓总神经的运动神经传导速度(MNCV)和感觉神经传导速度(SNCV)均高于治疗前,且观察组患者正中神经和腓总神经的MNCV与SNCV高于对照组,差异均有统计学意义(P<0.05);观察组治疗后的血流变指标低于治疗前与对照组,差异有统计学意义(P<0.05)。结论自拟糖痹康具有益气活血、化瘀通络的功效,能够有效治疗糖尿病周围神经病变,对临床具有指导意义,值得临床推广。

Objective To explore the clinical effect of Tangbikang in the treatment of qi deficiency and blood stasis diabetic peripheral neuropathy.Methods A total of 80 patients with diabetic peripheral neuropathy treated in our hospital from October 2016 to March 2017 were selected as the subjects,and divided into two groups by random number table method.In the control group,patients were treated with the basic treatment combined with Mecobalanin Tablets,and in the observation group,patients were treated with Tangbikang based on the treatment of the control group.Both groups were given one course of treatment for 8 weeks.The clinical efficacy,TCSS scores,changes of nerve conduction velocity,and changes of hemorheology indexes between the two groups were compared.Results The total effective rate in the observation group was 87.5%,which was higher than in the control group(67.5%),the difference was statistically significant(P<0.05).After treatment,the TCSS scores of the two groups were lower than that before treatment,and the TCSS scores of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).After treatment,MNCV and SNCV of median nerve and peroneal nerve in the two groups were higher than those before treatment,and MNCV and SNCV in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Hemorheological indexes in the observation group after treatment were better than those before treatment and the control group,and the differences were statistically significant(P<0.05).Conclusion The efficacy of Self-designed Tangbikang is benefiting qi for activating blood circulation and dispersing blood stasis and dredging collateral,it can effectively treat the diabetic peripheral neuropathy,has the guiding significance to the clinic treatment,and it deserves the clinical promotion.