纳米炭混悬注射液在甲状腺癌淋巴结清扫术中的应用效果

Application effect of Carbon Nanoparticles Suspension Injection in lymph node dissection of thyroid cancer

目的观察纳米炭混悬注射液用于甲状腺癌淋巴结清扫术的效果。方法选取本院2015年1月～2017年12月收治的60例分化型甲状腺癌患者作为研究对象,按随机数字表法分为观察组与对照组,各30例。观察组注射0.2 ml纳米炭混悬注射液,对照组注射0.2 ml亚甲蓝注射液,两组均行甲状腺全切术+中央区淋巴结清扫术+侧颈淋巴结清扫术。比较两组的淋巴结总检出数目、每例检出淋巴结数目、染色淋巴结检出数目、直径<2 mm淋巴结检出数目、淋巴结转移阳性率、淋巴结转移阳性率、转移淋巴结检出数目、染色的转移淋巴结检出数目、甲状旁腺误切率、术后并发症总发生率。结果观察组的淋巴结总检出数目、每例淋巴结检出数目、染色淋巴结检出数目、直径<2 mm淋巴结检出数目、转移淋巴结检出数目、染色的转移淋巴结检出数目均显著高于对照组(P<0.05)。两组的淋巴结转移阳性率与甲状旁腺误切率比较,差异无统计学意义(P>0.05)。观察组的术后并发症总发生率为10.00%,显著低于对照组的30.00%(P<0.05)。结论纳米炭混悬注射液应用于甲状腺癌手术中有助于全面了解淋巴结情况,可提高淋巴结清扫的准确性,有效保护甲状旁腺,能够减少并发症与医疗纠纷。

Objective To observe the effect of Carbon Nanoparticles Suspension Injection in lymph node dissection of thyroid cancer.Methods A total of 60 patients with differentiated thyroid cancer admitted to our hospital from January 2015 to December 2017 were enrolled in the study.They were divided into the observation group and the control group according to the random number table method,with 30 cases in each group.The observation group injected 0.2 ml Carbon Nanoparticles Suspension Injection,while the control group injected 0.2 ml Methylthioninium Chloride Injection.Both groups was treated with total thyroidectomy and central lymph node dissection combined with lateral cervical lymph node dissection.The number of total detected lymph nodes,the number of lymph nodes detected in each case,the number of stained lymph nodes detected,the number of lymph nodes for diameter<2 mm,the positive rate of lymph node metastases,the number of metastatic lymph nodes detected,the number of stained metastatic lymph nodes detected,the parathyroid error rate,the total incidence of postoperative complications were compared between two groups.Results The total number of lymph nodes,the number of lymph nodes detected in each case,the number of stained lymph nodes detected,the number of lymph nodes for diameter<2 mm,number of metastatic lymph nodes detected and the number of stained metastatic lymph nodes detected in the observation group were significantly higher than those in the control group(P<0.05).There were no significant difference in the positive rate of lymph node metastases,the parathyroid error rate between the two groups(P>0.05),and the total incidence of postoperative complications in the observation group was 10.00%,which was significantly lower than 30.00%of the control group(P<0.05).Conclusion The application of Carbon Nanoparticles Suspension Injection in thyroid cancer surgery can help to understand the situation of lymph nodes,improve the accuracy of lymph node dissection,effectively protect parathyroid glands,reduce complications and medical disputes.