摘要
本文设计并合成14个以芳香氨基取代为特征的青蒿苯基醚类化合物,并在人乳腺癌MCF-7细胞及其耐药株MCF-7/Adr中测试该类化合物的生长抑制活性。筛选结果表明,DC06对MCF-7细胞和MCF-7/Adr细胞均抑制活性显著,GI_(50)分别为0. 10μm和0. 012μm。
Fourteen artemisinin phenyl ethers substituted with aromatic amino were designed and synthesized herein.Their antiproliferative effects were tested in MCF-7cells and drug-resistant MCF-7/Adr cells.The result showed that a potential compound DC06 exbibited significant inhibitory effects against both MCF-7 and MCF-7/Adr cells,and the GI 50 was 0.10 μm and 0.012 μm respectivery.
作者
刘涛
曾昌广
周玥
钟杭
LIU Tao;ZENG Chang-guang;ZHOU Yue;ZHONG Hang(School of pharmaceutical sciences,Guizhou University,Guiyang 550025,China;Technical Department of Criminal Investigation Branch,Deyang Police Office,Deyang 618000,China)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2019年第1期9-14,共6页
Chemical Research and Application
基金
贵州省科技计划项目(黔科合基础[2017]1061)资助
贵州大学科研项目(贵大人基合字[2015]54)资助
关键词
青蒿苯基醚
耐药乳腺癌
生长抑制活性
artemisinin phenyl ether
drug-resistant breast cancer
antiproliferative effects
