肝细胞癌的鞘脂组学研究进展

Progress in research of sphingolipids in hepatocellular carcinoma

鞘脂是一系列新型的脂质生物调控分子,在调控细胞生长、分化、增殖以及凋亡等方面具有重要的生物学作用.鞘脂代谢紊乱可以诱发包括肝细胞癌(hepatocellular carcinoma, HCC)在内的多种疾病的发生.随着脂质组学技术的发展,越来越多的研究表明鞘脂在HCC发生、发展及转归中起到重要的作用.研究表明鞘脂可以作为诊断HCC的新型标志物,且调控鞘脂代谢通路可能成为治疗HCC的潜在靶点.本文从鞘脂的分类、代谢通路,鞘脂对肝细胞增殖与凋亡的影响,鞘脂在HCC的发生发展中的作用,以及鞘脂作为HCC诊断、治疗靶点的可能性等方面的研究现状做一综述.

Sphingolipids are a class of novel lipid bioregulatory molecules that play important roles in regulating cell growth,differentiation,proliferation,and apoptosis.Sphingolipid metabolism disorders could induce the development of various diseases including hepatocellular carcinoma(HCC).With the development of lipidomics,it has been demonstrated that sphingolipids play an increasingly essential role in the occurrence,development,and outcome of HCC.Studies have shown that sphingolipids can be used as a new biomarker for the diagnosis of HCC,and regulation of the sphingolipid metabolism pathway may be a potential target for the treatment of HCC.This paper reviews the current progress in research of sphingolipids with regard to their classification,metabolic pathways,role in the development of HCC,and the possibility as a target for diagnosis and treatment of HCC.