环氧合酶和脂氧合酶的抗肿瘤作用机制

Antitumor mechanisms of cyclooxygenase and lipoxygenase

类花生酸物质作为花生四烯酸(arachidonic acid,AA)的代谢产物,在肿瘤的发展和转移中起重要作用。环氧合酶(cyclooxygenase, COXs)-2和脂氧合酶(lipoxygenase, LOXs)是介导AA代谢的两种关键酶。目前COXs-2及其代谢产物前列腺素在使细胞增殖及凋亡失衡、促肿瘤血管增生等促肿瘤机制研究已取得大量成果,LOXs及其代谢产物白三烯(leukotrienes, LTs)-B4和羟-6,8,11,14-二十碳四烯酸(hydroxyeicosatetraenoic acid, HETEs)等与肿瘤的研究广受关注。已有研究表明LOXs介导的AA代谢产物LT-B4和5-HETE对多种肿瘤的发生发展有重要作用。COXs-2和LOXs双效抑制剂的应用为肿瘤的防治打开新的思路。

Eicosanoids,as the metabolic product of arachidonic acid,play an important role in tumor development and metastasis.Cyclooxygenase(COX)-2 and lipoxygenase(LOX)are two key enzymes that mediate the metabolism of arachidonic acid.So far,great progress has been made on the research of COX-2 and prostaglandins,and it has been demonstrated that they can induce the imbalance between cell growth and apoptosis as well as tumor angiogenesis.LOX and its metabolites,such as hydroxyeicosatetraenoic acid(HETE)and leukotriene(LT),have received more and more attention for their role in tumor development.Research has proved that LT-B4 and 5-HETE participate in the occurrence and development of multiple tumors.Therefore,COX and LOX dual inhibitors prove a new approach to anti-tumor therapy.