苏州地区0～6岁儿童维生素D营养状况调查分析

Serum vitamin D nutritional status of 0-6 years old children in Suzhou area

目的了解苏州地区儿童血清25(OH)D_3的水平状态,为0～6岁儿童合理补充维生素D提供科学依据。方法选取苏州市立医院儿童保健门诊2015年9月至2016年9月常规体检的15 010例儿童,其中男7 905例,女7 105例,通过采集其指尖血进行血清25(OH)D_3检测。结果 (1)苏州地区15 010例0～6岁儿童血清25(OH)D_3均值为(35.83±13.23)μg/L,男、女童血清25(OH)D_3均值分别为(36.48±13.25)、(35.11±13.16)μg/L,差异有统计学意义(P<0.01)。(2)0～<3、3～<6、6～<12、12～<36、36～<48、≥48个月年龄段儿童血清25(OH)D_3均值分别为(34.49±11.53)、(41.15±13.86)、(48.03±17.25)、(46.12±17.69)、(28.49±16.55)和(42.28±17.59)μg/L,除3～<6个月年龄段儿童与≥48个月比较差异无统计学意义外,其余各年龄段两两比较差异均有统计学意义(P<0.05)。(3)1～12月检测的血清25(OH)D_3中除1、2、3月与11月,7月与8月两两比较差异无统计学意义外,其余各月份之间比较差异均有统计学意义(P<0.01)。按维生素D水平判断标准分级,各月份血清25(OH)D_3分级构成比差异有统计学意义(P<0.01)。25(OH)D_3>30μg/L比例低于50%的月份为1、3、11月,比例在50%～60%为2、6、12月,比例在60%～70%为7、8、9月,比例>70%的月份为4、5和10月。结论苏州地区学龄儿童血清25(OH)D_3水平下降明显,应加强宣教,关注该年龄段儿童维生素D的摄入情况。

ObjectiveTo study the level of serum 25(OH)D 3 in children in suzhou area,and to provide scientific basis for the rational supplement of vitamin D for children aged 0-6 years.MethodsFrom September 2015 to September 2016,15 010 children underwent routine physical examination in the Children′s Health Clinic of Suzhou Municipal Hospital were selected,of whom 7 905 were male and 7 105 were female.The serum 25(OH)D 3 was detected by collecting their fingerling blood.Results(1)The mean serum 25(OH)D 3 of 15 010 children aged 0 to 6 in Suzhou was(35.83±13.23)μg/L,and the mean serum 25(OH)D 3 of male and female were(36.48±13.25)and(35.11±13.16)μg/L respectively,and the differences were statistically significant(P<0.01).(2)The mean level of serum 25(OH)D 3 of 0-<3,3-<6,6-<12,12-<36,36-<48 and≥48 months old children were(34.49±11.53),(41.15±13.86),(48.03±17.25),(46.12±17.69),(28.49±16.55)and(42.28±17.59)μg/L.The detection levels of serum 25(OH)D 3 between the age groups were statistically significant(P<0.05)except the children 3-<6 months and≥48 months.(3)From January to December,the detection levels of serum 25(OH)D 3 were statistically significant between different months(P<0.01)except in January,February,March and November,as well as July and August.The serum 25(OH)D 3 in each month was graded according to the vitamin D level,and the detection levels of serum 25(OH)D 3 between different months were statistically significant(P<0.01).The proportion of serum 25(OH)D 3 over 30μg/L was less than 50%in January,March and November.The ratio ranged from 50%to 60%in February,June and December.The ratio ranged from 60%to 70%in the July,August and September,while the proportion was over 70%in April,May and October.ConclusionThe level of serum 25(OH)D 3 in children in Suzhou area was decreased obviously,and health education should be strengthened,and attention should be paid to intaking of vitamin D in children.