乳腺癌患者血栓弹力图与常规凝血指标的相关性分析

Correlation analysis between thrombelastography and conventional coagulation indexes in breast cancer patients

目的分析乳腺癌患者血栓弹力图(TEG)与常规凝血指标的相关性,比较二者在乳腺癌患者凝血功能检测中的差异性。方法选择重庆大学附属肿瘤医院2016年11月至2017年5月同时检测了TEG、凝血象及血常规的180例乳腺癌患者,进行TEG参数与凝血功能指标、血小板计数的相关性分析,并对相关参数进一步做回归分析。比较TEG参数与常规凝血指标阳性率的差异。结果乳腺癌患者的TEG参数中凝血反应时间(R)与血细胞凝集块形成时间(K)、活化部分凝血活酶时间(APTT)呈正相关,与血细胞凝集块形成速率(α-Angle)、血凝块最大强度(MA)、凝血综合指数(CI)、D-二聚体(DD)、纤维蛋白(原)降解产物(FDPs)呈负相关;K与APTT、凝血酶时间(TT)呈正相关,与α-Angle、MA、纤维蛋白原(FIB)、DD、FDPs、血小板计数(PLT)呈负相关;α-Angle与MA、CI、FIB、DD、FDPs、PLT呈正相关;MA与CI、FIB、DD、FDPs、PLT呈正相关;CI与FIB、DD、FDPs、PLT呈正相关,α-Angle、MA、CI均与APTT、TT呈负相关(P<0.05);得到TEG各参数与凝血象指标的一元线性回归方程。TEG检测阳性率与常规凝血检测差异无统计学意义(P>0.05)。结论 TEG参数与血小板、常规凝血检测结果存在一定相关性,结果具有一致性。

ObjectiveTo analyze the correlation between thrombelastography(TEG)and conventional coagulation indexes in breast cancer patients,and to compare the differences between the two methods in the detection of coagulation function in breast cancer patients.MethodsRetrospectively analyzed the clinical data of 180 patients with breast cancer who were performed TEG,coagulation and blood test in the same day in our hospital from November 2016 to May 2017.Linear correlation and regression analysis were performed among the parameters.The differences of positive rates of TEG parameters and conventional coagulation indexes were compared.ResultsThe R value of TEG parameters of breast cancer patients was positively correlated with K and APTT,and negatively correlated withα-Angle,MA,CI,DD,FDPs.K was positively correlated with APTT and TT,and negatively correlated withα-Angle,MA,FIB,DD,FDPs and PLT.α-Angle was positively correlated with MA,CI,FIB,DD,FDPs and PLT.MA was positively correlated with CI,FIB,DD,FDPs and PLT.CI was positively correlated with FIB,DD,FDPs and PLT.α-Angle,MA and CI were all negatively correlated with APTT and TT,the difference were statistically significant(P<0.05).A linear regression equation of TEG parameters and coagulation indexes was obtained.There was no significant difference between TEG detection positive rate and conventional coagulation test(P>0.05).ConclusionThere are significant correlation between the TEG parameters and routine coagulation or platelet,and the results are consistent.