NLR和CRP对早期糖尿病肾病的诊断意义

Diagnostic significance of neutrophils to lymphocyte ratio and C reactive protein in the early stage of diabetic nephropathy

目的探讨中性粒细胞与淋巴细胞比值(NLR)和C反应蛋白(CRP)对早期糖尿病肾病(DN)的诊断价值。方法选取该院2型糖尿病患者120例,依据24h尿微量清蛋白水平分为单纯糖尿病(DM组,60例)、早期糖尿病肾病组(DN组,60例),同时选取同期体检健康者60例作健康对照组(NC组)。收集受试者的一般资料及临床指标,分析各组NLR和CRP的差异,采用Pearson相关分析尿微量清蛋白与各临床指标的相关性,并应用logistic回归分析DN的危险因素。结果 DN组NLR、CRP水平明显高于DM组和NC组,差异均有统计学意义(P<0.05);Pearson相关分析显示,24h尿微量清蛋白与NLR、HbA1c、CRP均呈正相关[相关系数(r)=0.40、0.52、0.39,P<0.05];logistic回归分析显示,中性粒细胞计数、NLR、CRP和HbA1c是影响DN发生的独立危险因素。结论 NLR和CRP在DN患者中明显升高,对于DN的早期诊断具有重要的预测价值。

ObjectiveTo investigate the diagnostic value of neutrophil to lymphocyte ratio (NLR) and C reactive protein (CRP) in early stage of diabetic nephropathy(DN).Methods Totally 120 cases of patients with type 2 diabetes mellitus were selected in the hospital.According to the level of 24 h urine microalbumin,the subjects were divided into simple diabetes group (DM group,60 cases) and early diabetic nephropathy group (DN group,60 cases).At the same time,60 healthy controls were selected as normal control group (NC group).The general data and clinical indicators of the subjects were collected.The differences of NLR and CRP among three groups were analyzed.Pearson analysis was used to analyze the correlation between urinary albumin and clinical indicators,while logistic regression analysis was used to analyze the risk factors of DN.ResultsThe levels of NLR and CRP in DN group were significantly higher than those of DM group and NC group.Pearson correlation analysis showed that the 24 h urine microalbumin was positively correlated with NLR,HbA1c and CRP (r =0.40,0.52,0.39, P <0.05).Besides,logistic regression analysis showed that the neutrophil counts,NLR,HbA1c and CRP are the risk factors of DN.ConclusionNLR and CRP are significantly increased in DN,which have important predictive value for the early diagnosis of DN.