血栓弹力图的临床应用新进展

Thromboelastography:clinical applications and new development

正常生理情况下,止凝血过程是由多种因素参与的动态平衡过程,包括一期止血(血管收缩和血小板血栓形成)、二期止血(凝血酶生成和纤维蛋白聚合)及纤维蛋白溶解。常规凝血试验只能反映某一环节异常,作用相对局限。血栓弹力图分析了血小板、凝血因子等多种因素的作用,能较全面地反映整个凝血过程,已被广泛应用于临床医疗。该文简要介绍血栓弹力图在临床上的应用新进展。

Under normal physiological conditions,hemostatic process is a dynamic balance process dependent on many factors.It involves interaction between primary hemostasis(vasoconstriction,platelet clot formation),secondary hemostasis(thrombin generation,fibrin polymerization)and fibrinolysis,and any abnormalities of the three may cause hemorrhagic or thrombotic diseases.Conventional coagulation tests are useful for a limited degree since they only reflect a portion of the coagulation cascade.Thromboelastography(TEG)provides a more complete picture of coagulation status,taking into account more factors involved in the clotting process,including platelet activity and clotting factors,which has been widely used in clinic.In this article,we will briefly discuss clinical applications and new development of TEG.