浙江汉族22个STR基因座多态性及法医学应用性

Polymorphism of 22 STR Loci in Zhejiang Han Population and Their Forensic Applicability

目的调查22个常染色体STR基因座在浙江汉族中的等位基因分布,并探讨其法医学应用价值。方法对浙江汉族512例无血缘关系个体,采用STRtyper-23comp常染色体补充位点试剂盒进行电泳检测,以Genemapper ID-X软件进行分析,获取其22个基因座的数据资料。结果 22个常染色体STR基因座的杂合度为0.6797～0.8789,个人识别能力为0.8558～0.9730,非父排除率为0.4446～0.7644,多态性信息总量为0.6477～0.8697,累积个人识别能力为1～4.1853×10-26。结论 22个常染色体STR基因座在浙江汉族人群中呈高度多态性,对法医学亲子关系鉴定具有较大价值,对法医学物证鉴定与研究有应用价值。

Objective To investigate the allelic distribution of 22 autosomal STR loci in Zhejiang Han population and to explore their forensic values.Methods 512 unrelated individuals were randomly selected from Zhejiang Han population and detected by STRtyper-23comp kit,plus the analysis by Genemapper ID-X software to the obtained data.Results The heterozygosity of 22 autosomal STR loci is 0.6797-0.8789,along with the probability of discrimination 0.8558-0.9730,the probability of exclusion 0.4446-0.7644,the polymorphism information content 0.6477-0.8697,and the cumulative individual recognition rate 1-4.1853×10-26.Conclusion The 22 autosomal STR loci are highly polymorphic in Zhejiang Han population,capable of being great value to the identification of forensic paternity,having applicability in forensic evidence identification.