有氧运动通过鸢尾素改善慢性心力衰竭的机制

Mechanism of aerobic exercise improving chronic heart failure by irisin

背景:慢性心力衰竭与心肌线粒体稳态异常以及心肌能量代谢紊乱等密切相关。解偶联蛋白2是位于线粒体内膜上的质子泵,与心肌的氧化应激、能量代谢和细胞凋亡关系密切,在慢性心力衰竭病理生理过程中起着极其重要作用。目的:总结鸢尾素对慢性心力衰竭的影响,讨论有氧运动通过鸢尾素改善慢性心力衰竭的机制。方法:应用计算机检索PubMed和CNKI等数据库从2001年至2018年收录的与鸢尾素和慢性心力衰竭相关的文献。英文检索词为:"aerobic exercise","Irisin","chronic heart failure",中文检索词为:"有氧运动","鸢尾素","慢性心力衰竭"。排除无关和重复文献,最后纳入53篇文章进行分析总结,包括8篇中文和45篇英文文献。结果与结论:鸢尾素可抑制活性氧生成,可以模拟有氧运动带来的良好效益,在有氧运动改善慢性心力衰竭中起着重要的作用,因此鸢尾素可作为运动治疗心力衰竭的潜在靶点。长期的有氧运动可能通过鸢尾素/活性氧/解耦联蛋白2途径改善心力衰竭过程。

BACKGROUND:Chronic heart failure is closely related to the homeostasis of myocardial mitochondria and disorders of myocardial energy metabolism.As a proton pump on the membrane of mitochondria,uncoupling protein 2 is closely related to myocardial oxidative stress,energy metabolism and cardiomyocyte apoptosis.It plays an extremely important part in the pathophysiological process of myocardium.OBJECTIVE:To review the effects of irisin on chronic heart failure and explore the mechanism of aerobic exercise improving chronic heart failure by irisin.METHODS:A computer-based retrieval of PubMed and CNKI databases was performed to search relevant articles concerning irisin and chronic heart failure published from 2001 to 2018,using the keywords“aerobic exercise,irisin,chronic heart failure”in English and Chinese,respectively.After removal of repetitive and irrelevant articles,53 eligible articles were finally reviewed,including 45 English and 8 Chinese articles.RESULTS AND CONCLUSION:Irisin may inhibit the production of reactive oxygen species and simulate the good benefits of aerobic exercise.Irisin plays an important role in aerobic exercise improving chronic heart failure and serves as a potential target for exercise therapy for heart failure.Long-term aerobic exercise may improve heart failure through the irisin/reactive oxygen species/uncoupling protein 2 pathway.