生长抑素治疗腹部手术后腹腔感染的疗效及对血清AMS的影响

Effect of Somatostatin on Abdominal Infection after Abdominal Surgery and its Influence on Serum AMS

目的:研究生长抑素治疗腹部手术后腹腔感染的疗效及对血清淀粉酶(amylase AMS)的影响。方法:选取2013年3月至2018年2月我院的79行腹部手术患者。按照简单随机数表法分为观察组(37例)和对照组(42例),对照组采用常规治疗,观察组在对照组的基础上,采用生长抑素治疗。观察两组患者治疗疗效,治疗疗效情况、临床症状消失时间(恶心呕吐、腹胀腹痛、肛门排气时间)及住院时间、血清AMS、腹水AMS水平、不良反应发生率。结果:治疗后,总有效率显著高于对照组[94.59%(35/37) vs66.66%(28/42)](P<0.05);各临床症状消失时间及住院时间均低于对照组[(1.89±0.70) d vs(4.01±1.21) d,(2.90±0.58) d vs(6.27±1.34) d,(3.76±0.82) d vs(5.80±1.35) d,(4.59±1.02) d vs(7.40±2.15) d](P <0.05);血清AMS、腹水AMS水平均显著低于对照组[(142.01±19.42) U/L vs(297.46±26.04) U/L,(124.21±18.47) U/L vs(305.98±31.27) U/L](P <0.05);不良反应总发生率低于对照组[8.10%(3/37) vs28.57%(12/42)](P<0.05)。结论:生长抑素治疗腹部手术后腹腔感染的疗效显著,能够有效改善患者的临床症状,促进术后恢复,减少不良反应,降低血清AMS,安全可靠。

Objective:To study effect of somatostatin on abdominal infection after abdominal operation and its influence on serum amylase.Methods:79 abdominal operations who received therapy from March 2013 to February 2018 in our hospital were selected as research objects.According to simple random number table,those patients were divided into the observation group(n=37)and the control group(n=42).The control group was treated with conventional therapy,while the observation group was on the basis of the control group,somatostatin was used.Then the therapeutic effect,disappearance time of clinical symptoms(nausea and vomiting,abdominal distension and abdominal pain,anal exhaust time),hospitalization time,serum AMS,ascites AMS level,incidence of adverse reactions of two groups after treatment were compared.Results:After treatment,the total effective rate of observation group was statistically higher than that in the control group [94.59%(35/37)vs 66.66%(28/42)](P<0.05); The time of disappearance of clinical symptoms and the time of hospitalization were lower than those of the control group[(1.89±0.70)d vs(4.01±1.21)d,(2.90±0.58)d vs(6.27±1.34)d,(3.76±0.82)d vs(5.80±1.35)d,(4.59±1.02)d vs(7.40±2.15)d](P<0.05); The levels of serum AMS and ascites AMS were significantly lower than those in control group [(142.01±19.42)U/L vs(297.46±26.04)U/L,(124.21±18.47)U/L vs(305.98±31.27)U/L](P<0.05); The total incidence of adverse reactions was lower than that of the control group[8.10%(3/37)vs 28.57%(12/42)](P<0.05).Conclusion:Somatostatin is effective in the treatment of abdominal infection after abdominal surgery.It can effectively improve clinical symptoms,promote postoperative recovery,reduce adverse reactions,and reduce serum AMS.It is safe and reliable.