老年脑梗死患者miR-145 IGF1R水平与颈动脉狭窄的相关性

The Correlation between the Levels of miR-145 and IGF1R and Carotid Artery Stenosis in Elderly Patients with Cerebral Infarction

目的:研究老年脑梗死患者血清miR-145、胰岛素样生长因子1受体(IGF1R)水平与颈动脉狭窄的相关性。方法:将2016年3月至2018年3月181例老年脑梗死患者,根据颈部超声检查结果分为颈动脉无狭窄组47例和狭窄组134例,采用北美症状性颈动脉内膜切除试验法(NASCET)将134例颈动脉狭窄患者分为轻度组(52例),中度组(43例)和重度组(39例)。检测受试者血清miR-145和IGF1R水平,分析血清miR-145和IGF1R在不同颈动脉狭窄程度患者中的水平变化,分析影响老年脑梗死患者颈动脉狭窄的危险因素。结果:狭窄组血清miR-145相对表达量显著低于无狭窄组,血清IGF1R水平显著高于无狭窄组(P<0.05);血清miR-145随患者颈动脉狭窄程度加重呈逐渐显著降低趋势(P<0.05),血清IGF1R水平随患者颈动脉狭窄程度加重呈逐渐显著升高趋势(P<0.05);血清miR-145水平与IGF1R水平呈显著负相关关系(r=0.539,P=0.000); miR-145是颈动脉狭窄的保护因素,IGF1R是颈动脉狭窄的危险因素。结论:老年脑梗死患者血清miR-145表达下调,IGF1R水平显著升高,与患者颈动脉狭窄程度密切相关,可作为老年脑梗死的治疗靶点。

Objective:To study the correlation between serum levels of microRNA-145 and insulin-like growth factor-1 receptor(IGF1R)and carotid artery stenosis in elderly patients with cerebral infarction.Methods:181 elderly patients with cerebral infarction admitted to our hospital from March 2016 to March 2018 were divided into 47 patients with no stenosis of carotid artery and 134 patients with stenosis of carotid artery according to the results of carotid ultrasonography.134 patients with carotid stenosis were divided into mild group(52 cases),moderate group(43 cases)and severe group(39 cases)by NASCET.Serum levels of miR-145 and IGF1R were measured.The changes of serum levels of miR-145 and IGF1R in patients with different degrees of carotid artery stenosis were analyzed.The risk factors of carotid artery stenosis in elderly patients with cerebral infarction were analyzed.Results:The relative expression of serum microRNA-145 in stenosis group was significantly lower than that in non-stenosis group,and the level of serum IGF1R was significantly higher than that in non-stenosis group(P<0.05).Serum microRNA-145 decreased gradually with the severity of carotid stenosis(P<0.05).Serum IGF1R level increased with the severity of carotid stenosis(P<0.05).Serum microRNA-145 level was negatively correlated with IGF1R level(r=0.539,P=0.000).Mir-145 was a protective factor for carotid stenosis,and IGF1R was a risk factor for carotid stenosis.Conclusion:The expression of serum microRNA-145 is down-regulated and the level of IGF1R is significantly increased in elderly patients with cerebral infarction,which is closely related to the degree of carotid artery stenosis and could be used as a therapeutic target for elderly patients with cerebral infarction.