胆汁酸代谢紊乱与消化道疾病的研究进展

Progress in understanding relationship between bile acid metabolic disorder and gut diseases

人体肠道中存在数量庞大的微生物,这些微生物依靠消化道内的营养存活;同时也通过自身代谢产物等物质影响肠神经-免疫功能.肠神经-免疫共同调控其消化与吸收等功能,维持肠道内的稳态.当肠道内的胆汁酸(bile acid, BA)代谢发生紊乱,肠神经系统(entericnervous system,ENS)和肠道内其他信号分子的正常功能受到影响,诱发肠道免疫调节改变,而肠道的常见疾病与此有关.本综述阐述肠道微生物从BA途径影响ENS或其他细胞及信号分子的正常调控功能,进而导致肠道功能失调的研究进展,为临床治疗提供理论依据.

There are a large number of microorganisms in the human intestine,which rely on the nutrition in the digestive tract to survive.At the same time,they affect the intestinal neuro-immune function through the metabolism substances produced by themselves.The enteric neuro-immune system regulates the functions of digestion and absorption so as to maintain the homeostasis in the intestine.intestinal bile acid metabolism disorder might induce gut dysfunction or intestinal immune imbalance.This review describes the effect of intestinal microbes on the enteric nervous system or other signal molecules of the bile acid pathway linked to some intestinal disorders,with an aim to provide a theoretical basis for clinical treatment of the related diseases.