摘要
肠嗜铬细胞(Enterochromaffin cell, EC)由肠上皮基底干细胞分化而来,由于其特殊的组织化学染色特性而得名. EC主要分泌5-羟色胺,并产生机体95%的5-羟色胺(5-hydroxytryptamine,5-HT).EC作为化学感受器通过肠-脑回路与神经细胞建立直接突触联系,感受胃肠道摄入的食物以及相关化学因子,并以此调控胃肠道吸收营养物质.另外, EC还参与肠道免疫调节功能.值得注意的是EC数量以及其分泌的5-HT浓度的变化与多种肠道疾病密切相关.总之,EC对胃肠道健康的作用不容小觑.
Enterochromaffin cells(ECs),known for their special histochemical characteristics,originate from enteroblasts.For their important role in physiological and pathophysiological conditions,ECs in the gut could synthesize and secrete about 95%of 5-hydroxytryptamine(5-HT)in the body,which is an important humoral factor.As a chemosensor,ECs can regulate nutrition absorption and satiety through the sensory neural pathways.In addition,ECs participate in immune regulation.What’s more,ECs and 5-HT are closely related to many kinds of gastrointestinal diseases.
作者
朱敏佳
杨泽俊
王菲菲
狄治杉
王跃秀
李利生
徐敬东
Min-Jia Zhu;Ze-Jun Yang;Fei-Fei Wang;Zhi-Shan Di;Yue-Xiu Wang;Li-Sheng Li;Jing-Dong Xu(Department of Physiology and Pathophysiology,Capital Medical University,Beijing 100069,China;International College,Capital Medical University,Beijing 100069,China)
出处
《世界华人消化杂志》
CAS
2019年第2期117-124,共8页
World Chinese Journal of Digestology
基金
国家自然科学基金Nos.81274173
81673671
81270443
首都医科大学创新基金No.XSKY2018008
CXZDS2018011~~
关键词
肠嗜铬细胞
5-HT
生理功能
免疫调节
肠道疾病
Enterochromaffin cells
5-hydroxytryptamine
Immune regulation
Physiological function
Intestinal disease
